{"id":"W4390744494","doi":"10.1073/pnas.2312455121","title":"Structure of a tripartite protein complex that targets toxins to the type VII secretion system","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Burroughs Wellcome Fund","keywords":"Effector; Secretion; Cytoplasm; Toxin; Cell biology; Function (biology); Extracellular; Biology; Microbial toxins; Pathogen; Domain (mathematical analysis); Bacteria; Microbiology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006722052,0.000347521,0.0003137343,0.0003249023,0.0005118899,0.0005362956,0.0005624263,0.0007261172,0.00230029],"category_scores_gemma":[0.0002362534,0.0002716698,0.0002874005,0.0002655529,0.0002791683,0.000407251,0.0002740031,0.0008051094,0.0009052214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009743167,"about_ca_system_score_gemma":0.0005423855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001633958,"about_ca_topic_score_gemma":0.0009162617,"domain_scores_codex":[0.999911,0.00001293075,0.000004294511,0.00002553575,0.00002883169,0.0000174536],"domain_scores_gemma":[0.9998134,0.00001580007,0.00003938558,0.00001559992,0.00003339368,0.00008254011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005982848,0.0002084478,0.001558245,0.0001871893,0.0000568701,0.001100304,0.0001288025,0.004765319,0.9799603,0.003152703,0.002286328,0.005997167],"study_design_scores_gemma":[0.0007087963,0.003933587,0.1670373,0.0002186114,0.0002214344,0.01001109,0.0008045207,0.2643387,0.454924,0.01027042,0.08712742,0.00040411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796539,0.001676238,0.01139504,0.0005753046,0.0001231978,0.0001018133,0.0009638968,0.0004013999,0.005109195],"genre_scores_gemma":[0.9804978,0.0005826147,0.0120365,0.0005071814,0.00003497413,0.00005681307,0.003161349,0.00004374927,0.00307893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00230029,"threshold_uncertainty_score":0.007695258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860194515565406,"score_gpt":0.2809278696265347,"score_spread":0.2523259244708806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}