{"id":"W4390747771","doi":"10.1186/s12974-024-03014-w","title":"A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice","year":2024,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Island University","funders":"National Health and Medical Research Council; Medical Research Council; Brain Foundation; Michael Smith Health Research BC; Monash University; National Imaging Facility","keywords":"Toxoplasma gondii; Traumatic brain injury; Neuroinflammation; Excitotoxicity; Pathophysiology; Medicine; White matter; Immunology; Neuroscience; Pathology; Biology; Internal medicine; Inflammation; Glutamate receptor; Magnetic resonance imaging; Psychiatry; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003238706,0.0008402482,0.0006369809,0.001311335,0.0004499016,0.0006192207,0.0004341866,0.001004992,0.003367826],"category_scores_gemma":[0.000201834,0.0005385813,0.0008748666,0.0004228909,0.0006784768,0.0006535283,0.0004703218,0.002891978,0.001068019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004132064,"about_ca_system_score_gemma":0.0005037328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218069,"about_ca_topic_score_gemma":0.001985007,"domain_scores_codex":[0.9994295,0.00005668471,0.00008341885,0.0001409295,0.0001286839,0.0001607795],"domain_scores_gemma":[0.9996275,0.00002070617,0.0001296681,0.00003401728,0.0000443815,0.0001438482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001976507,0.001066161,0.002191661,0.0003092065,0.00005108152,0.0003456516,0.0002576598,0.0001865952,0.9885759,0.0003862908,0.0005192098,0.004134059],"study_design_scores_gemma":[0.0003087229,0.009408565,0.04433846,0.0002484577,0.0002768578,0.001838177,0.0008618718,0.00263855,0.9251679,0.0008060856,0.01401638,0.00009011722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792994,0.003256579,0.005269719,0.0009109263,0.0003360324,0.0002236403,0.005718443,0.000441107,0.004544131],"genre_scores_gemma":[0.9628112,0.005267979,0.006524433,0.0007794669,0.00009915112,0.0007919214,0.004528988,0.000175949,0.01902089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003367826,"threshold_uncertainty_score":0.01126647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02221060548284031,"score_gpt":0.306561716581516,"score_spread":0.2843511110986757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}