{"id":"W4390749181","doi":"10.3390/medicines11010003","title":"Dimeric 3,5-Bis(benzylidene)-4-piperidones: Tumor-Selective Cytotoxicity and Structure-Activity Relationships","year":2024,"lang":"en","type":"article","venue":"Medicines","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Cytotoxicity; Chemistry; Apoptosis; Cytotoxic T cell; Cancer research; Cell culture; Cell cycle; Cell; Mechanism of action; Biochemistry; In vitro; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115091,0.0002844569,0.0001468433,0.0001118831,0.00006019941,0.0001060961,0.0001435262,0.0001162137,0.001202614],"category_scores_gemma":[0.0001008275,0.00008552737,0.0001383303,0.0001017279,0.0000861392,0.000149511,0.000103027,0.0003875729,0.0002926934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501927,"about_ca_system_score_gemma":0.0001159815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002252374,"about_ca_topic_score_gemma":0.0005768267,"domain_scores_codex":[0.9999621,0.000008010325,0.000003390401,0.000008166087,0.00001223231,0.000006168856],"domain_scores_gemma":[0.9999272,0.00001338795,0.0000320086,0.000005692684,0.00001117807,0.00001043956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002664191,0.0001734892,0.0009135891,0.0003541554,0.00001631148,0.0001118943,0.00002790476,0.002137667,0.980292,0.0001701447,0.0001508221,0.01538552],"study_design_scores_gemma":[0.0000909286,0.004508108,0.008613534,0.00002758411,0.00006542201,0.0007752373,0.00003086087,0.00380289,0.9712479,0.0001512363,0.01067355,0.00001279594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976258,0.01549026,0.004847809,0.0001996967,0.00002623121,0.00007965971,0.0003652907,0.00005940499,0.002673732],"genre_scores_gemma":[0.9885244,0.006590133,0.002921807,0.0000565687,0.00001360247,0.0000289847,0.0003738098,0.000006092267,0.001484576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202614,"threshold_uncertainty_score":0.004023135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471289364232488,"score_gpt":0.2532954211649301,"score_spread":0.2285825275226053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}