{"id":"W4390749181","doi":"10.3390/medicines11010003","title":"Dimeric 3,5-Bis(benzylidene)-4-piperidones: Tumor-Selective Cytotoxicity and Structure-Activity Relationships","year":2024,"lang":"en","type":"article","venue":"Medicines","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Cytotoxicity; Chemistry; Apoptosis; Cytotoxic T cell; Cancer research; Cell culture; Cell cycle; Cell; Mechanism of action; Biochemistry; In vitro; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214481,0.0002343104,0.0003312916,0.00005874642,0.000193613,0.0000576245,0.000109249,0.0001480428,0.0006753752],"category_scores_gemma":[0.0009330981,0.000150908,0.0000682864,0.000256354,0.0002274718,0.0001551781,0.00006205604,0.0004976764,0.00001000219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006613891,"about_ca_system_score_gemma":0.00005558018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543944,"about_ca_topic_score_gemma":0.00006636587,"domain_scores_codex":[0.9987948,0.00007627778,0.0001838526,0.0004797972,0.0002161759,0.0002491177],"domain_scores_gemma":[0.9984731,0.001110675,0.00005994978,0.0001948585,0.00003983031,0.0001215524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007130567,0.00006733911,0.05817915,0.0002725264,0.00008423322,0.0000555307,0.0002705759,0.000002713776,0.924984,0.0002403872,0.0008819792,0.01489031],"study_design_scores_gemma":[0.000434665,0.0001581034,0.2564463,0.0004466758,0.0001963748,0.0002134506,0.0006223927,0.002210934,0.7217873,0.003851393,0.01291032,0.0007220596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927347,0.001852168,0.0001917888,0.0006775616,0.0002233059,0.00008318454,0.00003261647,0.0002507074,0.003954009],"genre_scores_gemma":[0.9987342,0.0000669397,0.00009678701,0.00009475185,0.0005678035,0.00002167746,0.000008537973,0.0000187214,0.0003905166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2031966,"threshold_uncertainty_score":0.7394885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471289364232488,"score_gpt":0.2532954211649301,"score_spread":0.2285825275226053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}