{"id":"W4390750892","doi":"10.1038/s41587-023-02085-z","title":"In vivo human T cell engineering with enveloped delivery vehicles","year":2024,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; Lawrence Livermore National Laboratory; National Institute of General Medical Sciences; National Human Genome Research Institute; U.S. Department of Health and Human Services; National Institutes of Health; Houston Advanced Research Center; U.S. Department of Energy; Gilead Sciences; Natural Sciences and Engineering Research Council of Canada; Jane Coffin Childs Memorial Fund for Medical Research; Emerson Collective; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Genome editing; Cas9; CRISPR; Biology; Gene delivery; Genome engineering; Cell biology; Chimeric antigen receptor; Bystander effect; Antigen-presenting cell; T cell; Computational biology; Genetic enhancement; Gene; Immunology; Genetics; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006000396,0.0001532254,0.0001101346,0.0001955497,0.00002059795,0.00001644634,0.000169527,0.0008474233,0.00001453895],"category_scores_gemma":[0.00001170833,0.0001376354,0.00003450019,0.0002306674,0.00003660719,0.000003135835,0.00008036396,0.0005259775,0.000005888874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001662874,"about_ca_system_score_gemma":0.00002813734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008361879,"about_ca_topic_score_gemma":0.0000391035,"domain_scores_codex":[0.999234,0.000005455373,0.0001104849,0.0003498754,0.00006336909,0.000236773],"domain_scores_gemma":[0.9996989,0.000007185762,0.00001098638,0.0002396107,0.00001441567,0.00002892798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008538803,0.00001257078,0.00009274168,0.00005252393,0.00001764156,0.00006026665,0.00001298796,0.0004006544,0.9968742,0.0007931384,0.001158568,0.0005161802],"study_design_scores_gemma":[0.0001795693,0.000117915,0.0001561118,0.00002928706,0.000006775953,0.00003753673,0.00001427155,0.0004759224,0.862084,0.00001554469,0.1367172,0.0001658654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983709,0.01126664,0.003629885,0.0005145938,0.0002450024,0.0001147799,0.000008503765,0.0001329279,0.0003786758],"genre_scores_gemma":[0.9966015,0.0002605178,0.002209445,0.00008804027,0.0001274484,0.0000132871,0.00001148805,0.00003259948,0.000655672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1355587,"threshold_uncertainty_score":0.6536105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002086538383528644,"score_gpt":0.2383922722913049,"score_spread":0.2363057339077763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}