{"id":"W4390750892","doi":"10.1038/s41587-023-02085-z","title":"In vivo human T cell engineering with enveloped delivery vehicles","year":2024,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; Lawrence Livermore National Laboratory; National Institute of General Medical Sciences; National Human Genome Research Institute; U.S. Department of Health and Human Services; National Institutes of Health; Houston Advanced Research Center; U.S. Department of Energy; Gilead Sciences; Natural Sciences and Engineering Research Council of Canada; Jane Coffin Childs Memorial Fund for Medical Research; Emerson Collective; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Genome editing; Cas9; CRISPR; Biology; Gene delivery; Genome engineering; Cell biology; Chimeric antigen receptor; Bystander effect; Antigen-presenting cell; T cell; Computational biology; Genetic enhancement; Gene; Immunology; Genetics; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002704905,0.0003794634,0.0001678728,0.0001838771,0.0001462762,0.0005586098,0.0002786373,0.0005393984,0.00173181],"category_scores_gemma":[0.000134532,0.0001716575,0.0002541259,0.0001182592,0.0002433328,0.0002017934,0.0003304503,0.0006445497,0.0009524898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003304909,"about_ca_system_score_gemma":0.0002806406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004348638,"about_ca_topic_score_gemma":0.0004663337,"domain_scores_codex":[0.9997728,0.0000496642,0.00001712182,0.00005790159,0.00005736822,0.00004512668],"domain_scores_gemma":[0.9999441,0.0000110385,0.00001803949,0.000009471067,0.000007220423,0.00001016876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009740271,0.00005028223,0.0001090613,0.00004974892,0.00001025539,0.0001413869,0.00004154201,0.00053532,0.9915651,0.001717827,0.0004441659,0.005237872],"study_design_scores_gemma":[0.00002818545,0.0002486125,0.0001859585,0.000004852501,0.00001582063,0.0004434451,0.00001212635,0.001721233,0.9790761,0.0001645686,0.01809428,0.000004694843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6451797,0.003729931,0.3278158,0.0006923664,0.0005228192,0.0009032701,0.001395468,0.001476008,0.01828472],"genre_scores_gemma":[0.9289936,0.001520174,0.05347589,0.0001975134,0.00004168491,0.00032168,0.0008243108,0.0001687945,0.01445643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173181,"threshold_uncertainty_score":0.005793512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002086538383528644,"score_gpt":0.2383922722913049,"score_spread":0.2363057339077763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}