{"id":"W4390753808","doi":"10.1016/j.ccell.2023.12.019","title":"Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy","year":2024,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Spinal Cord Injury BC","funders":"National Cancer Institute; Cancer Research UK Cambridge Institute, University of Cambridge; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge; NIHR Cambridge Biomedical Research Centre; Medical Research Council; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Department of Health and Social Care; National Institute of General Medical Sciences; National Institute for Health and Care Research; Council for Chemical Research; National Institutes of Health; California Department of Fish and Game; Cancer Research UK; Memphis Research Consortium; BeiGene; Gilead Sciences; Merck KGaA; Wellcome Trust","keywords":"Bruton's tyrosine kinase; Autophagy; Tyrosine kinase; Cancer research; Protein-Tyrosine Kinases; Biology; Tyrosine-kinase inhibitor; Cell biology; Medicine; Signal transduction; Genetics; Cancer; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006337,0.0001994136,0.0003477033,0.0003021547,0.0002424794,0.0004924083,0.0001303438,0.0003542242,0.001831182],"category_scores_gemma":[0.000176698,0.0001089014,0.0002088262,0.0002240168,0.0002268651,0.0001924303,0.0001620072,0.000741708,0.0003134323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003942158,"about_ca_system_score_gemma":0.0001870089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005096489,"about_ca_topic_score_gemma":0.0007680923,"domain_scores_codex":[0.9997852,0.00004532335,0.00001328319,0.00002505383,0.00002985469,0.0001013412],"domain_scores_gemma":[0.9998528,0.0000293253,0.0000287485,0.00001874079,0.00001292985,0.00005749818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009154681,0.0009184237,0.007171202,0.0001057891,0.00007555234,0.0009312007,0.0001345187,0.0003523179,0.9649903,0.0004646356,0.001159643,0.01454168],"study_design_scores_gemma":[0.001672775,0.01492684,0.1919257,0.00003776631,0.0002722127,0.006555078,0.001042614,0.004562303,0.7515357,0.001002968,0.02642771,0.00003842881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970698,0.001127711,0.0001548013,0.00009895132,0.00002909133,0.00001655219,0.0001740933,0.00002622271,0.00130266],"genre_scores_gemma":[0.9986783,0.0002254268,0.00006906355,0.00004293741,0.00001043147,0.00001600424,0.0002410516,0.000003301238,0.0007134964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001831182,"threshold_uncertainty_score":0.006125867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357845105653216,"score_gpt":0.3228372433575173,"score_spread":0.3092587923009851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}