{"id":"W4390755692","doi":"10.1016/j.jaip.2024.01.009","title":"Flex-IT! Applying “Platform Trials” Methodology to Immunotherapy for Food Allergy in Research and Clinical Practice","year":2024,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; McMaster University","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; NIHR Imperial Biomedical Research Centre; Medical Research Council; Bausch Health; Pfizer; Hospital for Sick Children; AstraZeneca; Aimmune Therapeutics; Manchester Biomedical Research Centre; Food Allergy Canada; Australasian Society of Clinical Immunology and Allergy; Canadian Institutes of Health Research; Imperial College London; Imperial College Healthcare NHS Trust; National Institute for Health and Care Research; Regeneron Pharmaceuticals; Sanofi","keywords":"Medicine; FLEX; Oral immunotherapy; Food allergy; Immunotherapy; Clinical trial; Allergy; Clinical Practice; Medical physics; Immunology; Family medicine; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.3331291,0.003806557,0.007098549,0.008156095,0.001789435,0.01337015,0.004662469,0.007768174,0.1055222],"category_scores_gemma":[0.641099,0.003010008,0.01102718,0.00839364,0.006088071,0.009181471,0.01191142,0.01079474,0.0233153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002799606,"about_ca_system_score_gemma":0.01242625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000824408,"about_ca_topic_score_gemma":0.0009613251,"domain_scores_codex":[0.5423138,0.4162283,0.02044127,0.00837271,0.01107108,0.001573066],"domain_scores_gemma":[0.3296178,0.5380628,0.0286564,0.07841916,0.02089125,0.004352522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01384849,0.0005641881,0.002913867,0.07930474,0.01569642,0.0009844798,0.004586522,0.006610231,0.002174606,0.1915464,0.2417815,0.4399884],"study_design_scores_gemma":[0.01300363,0.003901939,0.003395735,0.03657059,0.006471862,0.0008079974,0.000850715,0.01703375,0.003393743,0.4098604,0.5042309,0.000478708],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.005739272,0.01631754,0.7523555,0.03178065,0.03122267,0.07739114,0.01756411,0.0201725,0.04745672],"genre_scores_gemma":[0.03377975,0.003629509,0.7323894,0.01482993,0.004241344,0.1984249,0.002527818,0.004442784,0.005734599],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.3331291,"threshold_uncertainty_score":0.8223705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4941446473285861,"score_gpt":0.5987956656494243,"score_spread":0.1046510183208382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}