{"id":"W4390765850","doi":"10.1146/annurev-cancerbio-062822-110356","title":"Therapeutic Discovery for Chromatin Complexes: Where Do We Stand?","year":2024,"lang":"en","type":"article","venue":"Annual Review of Cancer Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Epigenetics; Chromatin; Computational biology; Proteolysis; Limiting; Ubiquitin; Biology; Chromatin remodeling; Bioinformatics; Cancer research; Enzyme; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002080414,0.0001285194,0.0002566605,0.00002508086,0.00002721631,0.00001343135,0.0001514058,0.00009195143,0.00009816041],"category_scores_gemma":[0.00005035152,0.0000929417,0.000162323,0.00008699383,0.0001024691,0.00001049212,0.00004492565,0.00005015399,0.000004983698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001500947,"about_ca_system_score_gemma":0.0001769133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001436849,"about_ca_topic_score_gemma":0.0000186451,"domain_scores_codex":[0.9991402,0.00007152577,0.000306684,0.0002665626,0.00005720524,0.0001578469],"domain_scores_gemma":[0.9995461,0.0000319352,0.00008994067,0.0002010565,0.0001007228,0.00003032232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008802115,0.00004610103,0.0001196522,0.01806291,0.0003236903,7.008961e-7,0.00007446232,9.083005e-7,0.3470934,0.01443295,0.1244697,0.4952875],"study_design_scores_gemma":[0.0001404932,0.0003237033,0.00002048926,0.003659797,0.00003649978,0.000002113091,0.00003434707,0.000003186583,0.05156717,0.0007190278,0.9433781,0.0001151028],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002605484,0.9887136,0.003353163,0.00343504,0.000362477,0.000475754,0.0007627444,0.00001280074,0.0002789052],"genre_scores_gemma":[0.117235,0.879536,0.0002643372,0.001029842,0.0004304234,0.0002581563,0.0001443095,0.00002233081,0.001079566],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8189083,"threshold_uncertainty_score":0.3790053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456344592815502,"score_gpt":0.3523535107677421,"score_spread":0.3377900648395871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}