{"id":"W4390770263","doi":"10.1177/09636897231223293","title":"Ultrasound-Targeted Microbubble Destruction Increases BBB Permeability and Promotes Stem Cell–Induced Regeneration of Stroke by Downregulating MMP8","year":2024,"lang":"en","type":"article","venue":"Cell Transplantation","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"National Natural Science Foundation of China; Shanghai Jiao Tong University; Natural Science Foundation of Shanghai","keywords":"Medicine; Microbubbles; Stem cell; Homing (biology); Mesenchymal stem cell; Ischemia; Blood–brain barrier; Ultrasound; Pharmacology; Anesthesia; Pathology; Internal medicine; Central nervous system; Biology; Radiology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421063,0.0004841526,0.000395797,0.0003419735,0.00009165459,0.0002191203,0.0001388805,0.0002609332,0.0007999025],"category_scores_gemma":[0.000104671,0.00009774084,0.0002646142,0.0001283772,0.000234032,0.00024545,0.0001155304,0.0005136585,0.0001371095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409331,"about_ca_system_score_gemma":0.0002108756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003393883,"about_ca_topic_score_gemma":0.0006777876,"domain_scores_codex":[0.9998851,0.00001565051,0.00001314965,0.0000186898,0.00003756196,0.00002992857],"domain_scores_gemma":[0.9999381,0.000007740473,0.00002744474,0.000004271533,0.00001023475,0.000012228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000188725,0.00009887272,0.0001373597,0.00009039594,0.000007070985,0.0000361514,0.00001731721,0.00004663896,0.9955844,0.00005347621,0.00002972012,0.003709749],"study_design_scores_gemma":[0.00003528384,0.001592067,0.002418291,0.00001013855,0.00004024196,0.0001222529,0.00003559376,0.0006516935,0.9940188,0.00003084966,0.001041081,0.000003712862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912946,0.003168447,0.004714903,0.00009193908,0.00003421398,0.00004288678,0.00006082113,0.00008461832,0.00050766],"genre_scores_gemma":[0.9917327,0.003460229,0.003159461,0.00003981471,0.00002864548,0.0000780577,0.0001405681,0.00000950399,0.001351006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007999025,"threshold_uncertainty_score":0.002675891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00724534302019534,"score_gpt":0.1915239208946926,"score_spread":0.1842785778744973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}