{"id":"W4390770263","doi":"10.1177/09636897231223293","title":"Ultrasound-Targeted Microbubble Destruction Increases BBB Permeability and Promotes Stem Cell–Induced Regeneration of Stroke by Downregulating MMP8","year":2024,"lang":"en","type":"article","venue":"Cell Transplantation","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"National Natural Science Foundation of China; Shanghai Jiao Tong University; Natural Science Foundation of Shanghai","keywords":"Medicine; Microbubbles; Stem cell; Homing (biology); Mesenchymal stem cell; Ischemia; Blood–brain barrier; Ultrasound; Pharmacology; Anesthesia; Pathology; Internal medicine; Central nervous system; Biology; Radiology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084681,0.000153896,0.0001370727,0.00007413116,0.00009681847,0.00007155161,0.00005066274,0.0001033796,0.00002422566],"category_scores_gemma":[0.00000216302,0.0001570868,0.00004415105,0.0001577947,0.0000336577,0.0002393385,0.000001956463,0.0001094963,0.000004352069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003944324,"about_ca_system_score_gemma":0.00002291304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008911947,"about_ca_topic_score_gemma":0.00003745633,"domain_scores_codex":[0.9991993,0.00003815211,0.0002775103,0.0002339347,0.0001100977,0.0001409496],"domain_scores_gemma":[0.9996101,0.000146329,0.0000350493,0.0001223423,0.00003655264,0.00004968978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007961625,0.00003131345,0.001264952,0.0009790863,0.00001698528,4.863007e-7,0.001122554,0.001237082,0.9928757,0.00003569363,0.00003799713,0.002390195],"study_design_scores_gemma":[0.0002185162,0.00003192564,0.003752699,0.00006033286,0.0001071231,0.00002936981,0.0002540489,0.007158872,0.9880763,0.00008856698,0.00005315146,0.0001690545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862279,0.001442548,0.01106781,0.00001036046,0.0000850839,0.0002902345,0.0002526645,0.0002450196,0.0003783811],"genre_scores_gemma":[0.9972979,0.0005362371,0.001442842,0.000002755448,0.00004543146,0.00003971983,0.000514875,0.00003100252,0.00008925229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01106998,"threshold_uncertainty_score":0.6405813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00724534302019534,"score_gpt":0.1915239208946926,"score_spread":0.1842785778744973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}