{"id":"W4390779193","doi":"10.1158/1538-7445.dnarepair24-ia020","title":"Abstract IA020: Micronuclei are a nexus of DNA damage signaling and genomic instability","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Genome instability; Micronucleus test; DNA damage; Chromothripsis; Biology; Chromatin; DNA repair; Chromosome instability; Cell biology; Genetics; Cancer research; DNA; Gene; Chemistry; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003034085,0.0004009828,0.0004137606,0.001158194,0.0006513936,0.001280277,0.0004872086,0.0009462356,0.01106653],"category_scores_gemma":[0.0002530857,0.0002196101,0.0001580626,0.000492621,0.0006946043,0.0006434167,0.0007992907,0.001250444,0.003209234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009307882,"about_ca_system_score_gemma":0.0004802487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001327262,"about_ca_topic_score_gemma":0.002628548,"domain_scores_codex":[0.9998053,0.00001625753,0.00001598351,0.00005586677,0.00007984821,0.00002683446],"domain_scores_gemma":[0.9997296,0.00003381342,0.00005859756,0.00001520267,0.00006924904,0.00009347884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008374983,0.00007364775,0.002619121,0.0006172776,0.00003343179,0.001059732,0.0001738526,0.0002695567,0.9073693,0.004096731,0.0248213,0.05802862],"study_design_scores_gemma":[0.00005358425,0.0005099534,0.06544196,0.0001897451,0.00007073189,0.006328104,0.0004021944,0.001819604,0.7124405,0.008380202,0.204299,0.00006441256],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.5769781,0.1482695,0.04344608,0.0333465,0.01126574,0.000679056,0.0121125,0.004262045,0.1696404],"genre_scores_gemma":[0.7195346,0.03340973,0.01769237,0.003587618,0.002241191,0.0002080444,0.008106073,0.000335754,0.2148846],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01106653,"threshold_uncertainty_score":0.03702122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0641664662003624,"score_gpt":0.3693618925466047,"score_spread":0.3051954263462423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}