{"id":"W4390783145","doi":"10.3390/cells13020122","title":"The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Medical Research Council; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; UK Research and Innovation","keywords":"ARDS; microRNA; Extracellular vesicles; Sepsis; Acute respiratory distress; Microvesicles; Mesenchymal stem cell; Microvesicle; Stromal cell; Function (biology); Bioinformatics; Medicine; Biology; Computational biology; Immunology; Cancer research; Cell biology; Genetics; Lung; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002233762,0.0002449912,0.0003653951,0.00007222233,0.00003696465,0.00003159636,0.000207564,0.0002593254,0.000006622043],"category_scores_gemma":[0.00002327403,0.0001643005,0.0002547946,0.000126517,0.0001005598,0.000001304657,0.00008347523,0.0002369252,0.00002440761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007844529,"about_ca_system_score_gemma":0.0001506967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000676783,"about_ca_topic_score_gemma":0.00001153197,"domain_scores_codex":[0.9989244,0.0001504072,0.0002458344,0.000408064,0.0001051318,0.0001661596],"domain_scores_gemma":[0.9993415,0.0000412006,0.0001338332,0.0004052762,0.00003487051,0.00004335796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007744331,0.0001796986,4.551969e-7,0.007615608,0.0007218106,0.00003263474,0.0001542819,0.000002547783,0.2117909,0.005100252,0.00162256,0.7727018],"study_design_scores_gemma":[0.0001617999,0.0002057102,0.000001187841,0.001883949,0.0007258161,0.00001368768,0.0003141833,0.000005674145,0.08854449,0.003288557,0.9045432,0.0003117692],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002464421,0.9983596,0.0000745596,0.00003304557,0.0002635557,0.0004155661,0.00004898835,0.000006164514,0.0005521104],"genre_scores_gemma":[0.004039587,0.9945723,0.00003754063,0.00003554661,0.0000834116,0.00004680675,0.00002484214,0.00004888812,0.001111101],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9029206,"threshold_uncertainty_score":0.6699979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822314788850878,"score_gpt":0.3508534454443079,"score_spread":0.3226302975557991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}