{"id":"W4390783145","doi":"10.3390/cells13020122","title":"The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Medical Research Council; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; UK Research and Innovation","keywords":"ARDS; microRNA; Extracellular vesicles; Sepsis; Acute respiratory distress; Microvesicles; Mesenchymal stem cell; Microvesicle; Stromal cell; Function (biology); Bioinformatics; Medicine; Biology; Computational biology; Immunology; Cancer research; Cell biology; Genetics; Lung; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006605497,0.0007601358,0.001109337,0.00150206,0.0002246127,0.0009534569,0.0006475118,0.001368416,0.002150409],"category_scores_gemma":[0.0006418481,0.0002177262,0.0004542403,0.001265063,0.0005476178,0.001477346,0.0006778939,0.002356941,0.001178542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005317283,"about_ca_system_score_gemma":0.000813895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000417135,"about_ca_topic_score_gemma":0.0008190282,"domain_scores_codex":[0.9998292,0.00003998235,0.00002462104,0.00002497209,0.00006186548,0.00001936527],"domain_scores_gemma":[0.9997213,0.0001732002,0.00002235556,0.000007086424,0.0000526215,0.0000232932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001159165,0.00009033585,0.000116455,0.01573668,0.00008606272,0.0002739085,0.0001049294,0.0005227904,0.004983031,0.01404435,0.02408119,0.9398444],"study_design_scores_gemma":[0.0000156446,0.0001561754,0.0003916377,0.002695833,0.00006406719,0.001033126,0.00006119675,0.0001288303,0.0008433296,0.003534917,0.99106,0.000015305],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009267896,0.9985003,0.0001577378,0.0003176433,0.0002761792,0.000002542225,0.000007379725,0.000005016196,0.000640447],"genre_scores_gemma":[0.0006379876,0.9983585,0.0002017411,0.0002371715,0.0001786342,0.000005706979,0.00001252912,0.000001558137,0.0003660527],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002150409,"threshold_uncertainty_score":0.007193863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822314788850878,"score_gpt":0.3508534454443079,"score_spread":0.3226302975557991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}