{"id":"W4390788205","doi":"10.1101/2024.01.09.574617","title":"SURF2 is a MDM2 antagonist in triggering the nucleolar stress response","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Centre National de la Recherche Scientifique; Institute of Cancer Research; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Ribosome; Mdm2; Cell biology; Translation (biology); Biology; Apoptosis; Chemistry; Genetics; Messenger RNA; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267269,0.0003082264,0.0002420154,0.0001591445,0.000143613,0.0001840762,0.0002004138,0.0002843699,0.003630602],"category_scores_gemma":[0.0001194123,0.0001095917,0.0001759777,0.00008415174,0.0001645713,0.0001142596,0.0001697822,0.0003308128,0.000702224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001478531,"about_ca_system_score_gemma":0.0001120529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002417479,"about_ca_topic_score_gemma":0.0002521401,"domain_scores_codex":[0.9999254,0.00001746989,0.000005778715,0.00001080766,0.00002109843,0.00001947341],"domain_scores_gemma":[0.9999453,0.00001334026,0.000007957137,0.000006885422,0.000005710187,0.00002076968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000456095,0.00003954138,0.0001211258,0.00004207352,0.000009720131,0.00006596961,0.000003842002,0.0001049497,0.9978583,0.0001064527,0.0002254503,0.0009663709],"study_design_scores_gemma":[0.00003491185,0.0002851302,0.001150433,0.000004228161,0.000008385591,0.0001814745,0.000008463693,0.0007794079,0.9939168,0.00005264072,0.003574132,0.000003890829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872344,0.003412296,0.002732851,0.0003590109,0.0001487837,0.00003687956,0.0009525128,0.0001781326,0.004945091],"genre_scores_gemma":[0.9888723,0.0008078009,0.001729932,0.00008432136,0.00004534767,0.00003065394,0.001329331,0.00005154467,0.007048654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003630602,"threshold_uncertainty_score":0.01214558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094497686201137,"score_gpt":0.2369736287811472,"score_spread":0.2260286519191358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}