{"id":"W4390789343","doi":"10.1038/s41514-023-00128-y","title":"Cholesterol biosynthetic pathway induces cellular senescence through ERRα","year":2024,"lang":"en","type":"article","venue":"npj Aging","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Senescence; Cell biology; Biology; Phenotype; Mitochondrion; Endogeny; Mevalonate pathway; Biosynthesis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695298,0.0002025647,0.0001231908,0.00003872912,0.0001040942,0.0001416081,0.0002670859,0.000162612,0.00003545352],"category_scores_gemma":[0.00003462977,0.0001803343,0.00009789781,0.0001550287,0.00009780297,0.00001384358,0.0001209533,0.0001817055,0.00008325672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001990849,"about_ca_system_score_gemma":0.0001229258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001455285,"about_ca_topic_score_gemma":0.00000217965,"domain_scores_codex":[0.9987563,0.0000494376,0.0001909967,0.0005218278,0.0001688927,0.0003125627],"domain_scores_gemma":[0.9995034,0.000014876,0.00003777944,0.0003470063,0.00003958495,0.00005737053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003111782,0.00001609597,0.0002436287,0.0001552535,0.00002708147,0.00002651986,0.0002903547,0.00001305996,0.9912406,0.0001894346,0.0003076729,0.007487165],"study_design_scores_gemma":[0.00009561628,0.00004642035,0.00003654807,0.0001511926,0.00001655477,0.00004129915,0.0001324227,0.0001064392,0.9085272,0.0002058602,0.09041864,0.0002218332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698167,0.008107915,0.01504354,0.0002939666,0.0006168284,0.0001118647,0.000007185803,0.00009033641,0.005911694],"genre_scores_gemma":[0.9969286,0.0003885693,0.0004903302,0.0002839439,0.0005447164,0.00001757986,0.00004360949,0.00004273847,0.001259901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09011097,"threshold_uncertainty_score":0.7353819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128649585926902,"score_gpt":0.2507043423846977,"score_spread":0.2394178465254287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}