{"id":"W4390790136","doi":"10.1016/j.clim.2024.109901","title":"Favipiravir induces HuNoV viral mutagenesis and infectivity loss with clinical improvement in immunocompromised patients","year":2024,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; UCLH Biomedical Research Centre; NIHR BioResource; Manchester Biomedical Research Centre; Vlaamse regering; Rosetrees Trust; University College London Hospitals NHS Foundation Trust; Fonds Wetenschappelijk Onderzoek; National Institute for Health and Care Research; Great Ormond Street Hospital Charity; KU Leuven; Great Ormond Street Hospital for Children; Wellcome Trust","keywords":"Favipiravir; Infectivity; Virology; Biology; Virus; Serial passage; RNA-dependent RNA polymerase; Nitazoxanide; Mutagenesis; Antiviral drug; RNA; Mutation; Medicine; Genetics; Disease; Immunology; Gene; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348033,0.0001802087,0.0002627832,0.00008518519,0.0001675513,0.0001876106,0.00008357809,0.0002171658,0.001093992],"category_scores_gemma":[0.0004670067,0.00008025069,0.0001619834,0.00006283651,0.0001711048,0.0001172338,0.0001460583,0.0005030207,0.0001859257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001577968,"about_ca_system_score_gemma":0.0001203713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000282926,"about_ca_topic_score_gemma":0.0005009651,"domain_scores_codex":[0.9999328,0.00001996562,0.000006353749,0.00001453788,0.000008736713,0.00001776523],"domain_scores_gemma":[0.9998354,0.00004021656,0.00004285626,0.00001594243,0.00001418187,0.00005140843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008262277,0.001540471,0.1992927,0.0003780834,0.0001473352,0.02373637,0.0007192297,0.0005434793,0.6566604,0.0003238241,0.001518548,0.1068772],"study_design_scores_gemma":[0.000411575,0.0294405,0.8084956,0.00007137901,0.0001694098,0.06021219,0.0004756761,0.001441581,0.09078515,0.0002481193,0.008214592,0.00003440745],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976134,0.0006220882,0.0002521434,0.00007221508,0.0000102084,0.00002839231,0.00004188634,0.00003284281,0.001326845],"genre_scores_gemma":[0.9993136,0.0001192367,0.0001077894,0.00005789023,0.000006037475,0.000006241791,0.00004783641,0.000002149962,0.0003393168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093992,"threshold_uncertainty_score":0.003659725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04386557209523963,"score_gpt":0.4009675583198195,"score_spread":0.3571019862245798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}