{"id":"W4390791007","doi":"10.1038/s44220-023-00187-w","title":"Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo","year":2024,"lang":"en","type":"article","venue":"Nature Mental Health","topic":"Treatment of Major Depression","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Global Health Research; University Health Network; McMaster University; University of Calgary; St. Joseph’s Healthcare Hamilton; Baycrest Hospital","funders":"National Institute of Mental Health; National Institute on Aging; Fundamental Research Funds for the Central Universities; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Fok Ying Tong Education Foundation; Beijing Nova Program; Canadian Institutes of Health Research; NIHR Maudsley Biomedical Research Centre; Oxford Health NHS Foundation Trust; Cumming School of Medicine, University of Calgary; Mathison Centre for Mental Health Research and Education; Fok Ying Tung Education Foundation; Faculty of Health and Medical Sciences, University of Western Australia; Rotman Research Institute, Baycrest; Natural Science Foundation of Chongqing; Chinese Academy of Medical Sciences; Sichuan University; Victoria General Hospital Foundation; National Natural Science Foundation of China; Lister Institute of Preventive Medicine; National Institutes of Health; H. Lundbeck A/S; Rosetrees Trust; McMaster University; University of Oxford; National Institute for Health and Care Research; Wellcome; National Institute on Drug Abuse; South London and Maudsley NHS Foundation Trust; Government of Canada; Otsuka Canada Pharmaceutical; Hersh Foundation; Valeant Pharmaceuticals International; Wellcome Trust; King's College London; Neurocrine Biosciences; West China Hospital, Sichuan University; University of East London; Perelman School of Medicine, University of Pennsylvania; Sage Therapeutics; University of Texas Southwestern Medical Center; Michael Smith Health Research BC; Medical Research Council; Servier; Patient-Centered Outcomes Research Institute; Otsuka Pharmaceutical; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Lundbeckfonden; Eli Lilly and Company; American Foundation for Suicide Prevention; LivaNova; U.S. Department of Health and Human Services; William K. Warren Foundation; Ontario Brain Institute; Canadian Institute for Advanced Research; Sunovion; University of Pennsylvania; National Institute of Biomedical Imaging and Bioengineering; Rigshospitalet","keywords":"Antidepressant; Major depressive disorder; Placebo; Placebo response; Antidepressant medication; Psychiatry; Medicine; Depression (economics); Psychology; Alternative medicine; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000429956,0.000333212,0.000480419,0.0005487272,0.0002351665,0.00003972628,0.0001625506,0.0002438406,0.00009674198],"category_scores_gemma":[0.0002567285,0.0001985388,0.00004954704,0.0005946048,0.0001268715,0.000125584,0.000156892,0.000625001,0.00002244864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006014207,"about_ca_system_score_gemma":0.000875165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000292028,"about_ca_topic_score_gemma":0.001311753,"domain_scores_codex":[0.9972683,0.0002902809,0.000434504,0.0007965504,0.0007481648,0.0004622639],"domain_scores_gemma":[0.9978464,0.000691082,0.00008843268,0.0006560876,0.00003333876,0.0006846816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04678512,0.007087751,0.7265521,0.0009989275,0.001636548,0.002701534,0.01769853,0.00003329869,0.00376122,0.001735644,0.07079723,0.1202121],"study_design_scores_gemma":[0.02572528,0.005319959,0.8858573,0.003528767,0.0004007853,0.00124889,0.001067869,0.0007067635,0.001211532,0.0001171152,0.07431641,0.0004992606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8599179,0.011682,0.00004720384,0.1246693,0.0002364235,0.002806077,0.0003473851,0.0001801495,0.0001136292],"genre_scores_gemma":[0.9919095,0.001286769,0.003026817,0.002174449,0.00007467339,0.0004272644,0.0002669141,0.00006177039,0.0007718331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1593053,"threshold_uncertainty_score":0.8096179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009884036739564232,"score_gpt":0.3330045478623511,"score_spread":0.3231205111227868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}