{"id":"W4390791007","doi":"10.1038/s44220-023-00187-w","title":"Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo","year":2024,"lang":"en","type":"article","venue":"Nature Mental Health","topic":"Treatment of Major Depression","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Global Health Research; University Health Network; McMaster University; University of Calgary; St. Joseph’s Healthcare Hamilton; Baycrest Hospital","funders":"National Institute of Mental Health; National Institute on Aging; Fundamental Research Funds for the Central Universities; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Fok Ying Tong Education Foundation; Beijing Nova Program; Canadian Institutes of Health Research; NIHR Maudsley Biomedical Research Centre; Oxford Health NHS Foundation Trust; Cumming School of Medicine, University of Calgary; Mathison Centre for Mental Health Research and Education; Fok Ying Tung Education Foundation; Faculty of Health and Medical Sciences, University of Western Australia; Rotman Research Institute, Baycrest; Natural Science Foundation of Chongqing; Chinese Academy of Medical Sciences; Sichuan University; Victoria General Hospital Foundation; National Natural Science Foundation of China; Lister Institute of Preventive Medicine; National Institutes of Health; H. Lundbeck A/S; Rosetrees Trust; McMaster University; University of Oxford; National Institute for Health and Care Research; Wellcome; National Institute on Drug Abuse; South London and Maudsley NHS Foundation Trust; Government of Canada; Otsuka Canada Pharmaceutical; Hersh Foundation; Valeant Pharmaceuticals International; Wellcome Trust; King's College London; Neurocrine Biosciences; West China Hospital, Sichuan University; University of East London; Perelman School of Medicine, University of Pennsylvania; Sage Therapeutics; University of Texas Southwestern Medical Center; Michael Smith Health Research BC; Medical Research Council; Servier; Patient-Centered Outcomes Research Institute; Otsuka Pharmaceutical; National Institute of General Medical Sciences; National Alliance for Research on Schizophrenia and Depression; Lundbeckfonden; Eli Lilly and Company; American Foundation for Suicide Prevention; LivaNova; U.S. Department of Health and Human Services; William K. Warren Foundation; Ontario Brain Institute; Canadian Institute for Advanced Research; Sunovion; University of Pennsylvania; National Institute of Biomedical Imaging and Bioengineering; Rigshospitalet","keywords":"Antidepressant; Major depressive disorder; Placebo; Placebo response; Antidepressant medication; Psychiatry; Medicine; Depression (economics); Psychology; Alternative medicine; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004373967,0.0001997926,0.0003392921,0.0005704805,0.0002548198,0.0003189301,0.0001989208,0.0003568516,0.0005662941],"category_scores_gemma":[0.001525506,0.0001207711,0.0002685499,0.0004484853,0.0002057444,0.0001931922,0.0002199154,0.0002126512,0.00009607639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249066,"about_ca_system_score_gemma":0.0001318754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003132784,"about_ca_topic_score_gemma":0.005424152,"domain_scores_codex":[0.9997041,0.000116275,0.00004193027,0.00006750447,0.00004647755,0.00002366199],"domain_scores_gemma":[0.9994173,0.0001068802,0.0003073018,0.00004303821,0.00004708898,0.00007846639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001331496,0.00006260053,0.9939445,0.00001376717,0.0001886477,0.00008360411,0.00008553141,0.00009922148,0.001778276,0.00001710408,0.00009644742,0.002298773],"study_design_scores_gemma":[0.00001822457,0.0001375294,0.9994577,0.000001606059,0.00001926748,0.00008997489,0.00004001173,0.0001177833,0.00006687202,0.00001703499,0.00003235561,0.000001579134],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995298,0.0001113754,0.00004153998,0.00001538088,0.000002095011,0.000005746588,0.0001817879,0.000001984991,0.0001102316],"genre_scores_gemma":[0.9995547,0.00002867548,0.00006893668,0.00001256609,0.000002875014,0.000005611857,0.000291843,5.741661e-7,0.00003415328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003132784,"threshold_uncertainty_score":0.006229103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009884036739564232,"score_gpt":0.3330045478623511,"score_spread":0.3231205111227868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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