{"id":"W4390792399","doi":"10.1007/s00018-023-05029-7","title":"Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice","year":2024,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Ministero dell'Università e della Ricerca; Sentinelle Nord, Université Laval; Australian Government; Université Laval","keywords":"Phenotype; Depolarization; Endocannabinoid system; Knockout mouse; Neuroscience; Excitatory postsynaptic potential; Biology; Chemistry; Cell biology; Endocrinology; Inhibitory postsynaptic potential; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138516,0.0005358119,0.0004073888,0.0004551701,0.0001068281,0.0002877575,0.0003443446,0.0004052466,0.001248894],"category_scores_gemma":[0.0001417645,0.0003402867,0.0003119608,0.0001627853,0.0003391516,0.0003572204,0.0002483546,0.0009490105,0.0003771006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002592843,"about_ca_system_score_gemma":0.000170964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005225646,"about_ca_topic_score_gemma":0.001199594,"domain_scores_codex":[0.9998522,0.0000124543,0.0000268449,0.00004634824,0.00003248838,0.00002960999],"domain_scores_gemma":[0.9996891,0.00002466537,0.000143452,0.000018088,0.00001736592,0.0001072908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001061152,0.00001596502,0.0001262938,0.00002021406,0.00000372463,0.00006686062,0.00002053983,0.00001655073,0.9992093,0.00003808874,0.00001037094,0.0003659035],"study_design_scores_gemma":[0.00003723061,0.0007005539,0.01861166,0.00002100989,0.00002854374,0.0006809549,0.00009513299,0.0006011174,0.9779594,0.0001160051,0.001138304,0.00001008987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956863,0.0008067508,0.002126814,0.00006670773,0.00002540388,0.00002413353,0.0005538111,0.00009823157,0.0006118414],"genre_scores_gemma":[0.9905061,0.001202306,0.002542631,0.00007170505,0.00001142768,0.00007654751,0.0006667243,0.0000841533,0.0048383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248894,"threshold_uncertainty_score":0.004177988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115848457256156,"score_gpt":0.2646666768393776,"score_spread":0.253081831113762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}