{"id":"W4390794854","doi":"10.1182/bloodadvances.2023011442","title":"Determinants of bleeding before and during immune tolerance in 222 boys with severe hemophilia A and inhibitors >5 BU","year":2024,"lang":"en","type":"article","venue":"Blood Advances","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Novo Nordisk; Sanofi; Swedish Orphan Biovitrum; CSL Behring; Bayer; Pfizer","keywords":"Medicine; Titer; Hazard ratio; Internal medicine; Prothrombin complex concentrate; Regimen; Gastroenterology; Prospective cohort study; Immune tolerance; Confidence interval; Immunology; Immune system; Antibody; Warfarin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061065,0.0001497236,0.0003255906,0.0001645026,0.00005748395,0.00002231444,0.00003880489,0.00005314986,0.000009915187],"category_scores_gemma":[0.00002559261,0.0001001407,0.00002818003,0.0002601944,0.0001386684,0.0002307281,0.00005145468,0.0001536747,0.000001487491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001719396,"about_ca_system_score_gemma":0.00004199687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002292773,"about_ca_topic_score_gemma":0.0001542462,"domain_scores_codex":[0.9990126,0.00001242339,0.0002231345,0.0002913867,0.0002122087,0.0002482219],"domain_scores_gemma":[0.9996877,0.00004390835,0.00003500596,0.0001198092,0.00002870387,0.00008491198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002376161,0.0001183824,0.9451864,0.002396942,0.00005184421,0.000544303,0.001159769,0.000006460674,0.02603169,0.00001354557,0.000001903757,0.02425113],"study_design_scores_gemma":[0.007815926,0.001400584,0.8049158,0.01314528,0.0002673311,0.002254778,0.0008597219,0.0004430715,0.1670171,0.0003313247,0.001109336,0.0004397021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974097,0.02503933,3.272124e-7,0.0002271525,0.00004935834,0.0002940316,0.000006870901,0.00003013874,0.0002557506],"genre_scores_gemma":[0.9966257,0.001827927,0.0005530223,0.00000528046,0.00009256137,0.00002117366,0.000003009232,0.00001960605,0.0008517586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1409854,"threshold_uncertainty_score":0.4083619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009651476060200632,"score_gpt":0.2805960534827083,"score_spread":0.2709445774225077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}