{"id":"W4390797005","doi":"10.1101/2024.01.10.575040","title":"Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institutes of Health; University of Wisconsin-Madison","keywords":"RYR1; Ryanodine receptor; Malignant hyperthermia; Propofol; Skeletal muscle; Anesthetic; Chemistry; Endoplasmic reticulum; Ryanodine receptor 2; Biophysics; Sarcomere; Pharmacology; Cell biology; Biochemistry; Endocrinology; Biology; Myocyte; Medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006532756,0.0002408864,0.0001734166,0.00006562458,0.0001215491,0.0001501638,0.0001741726,0.0002104857,0.001266409],"category_scores_gemma":[0.0001421984,0.00008566025,0.0002306144,0.00004363106,0.0001608704,0.0001210606,0.0001996393,0.0002620713,0.0003066793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001262357,"about_ca_system_score_gemma":0.000138187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006842493,"about_ca_topic_score_gemma":0.0006993248,"domain_scores_codex":[0.9999191,0.00001934667,0.000005338587,0.00001357488,0.00002247685,0.00002008262],"domain_scores_gemma":[0.9999354,0.00001907754,0.00002429157,0.000005729391,0.000007163747,0.0000082941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001892897,0.00002351069,0.0005241849,0.00009495009,0.00001887749,0.00006645959,0.0000120592,0.0001867068,0.9963894,0.00009862434,0.00007034933,0.002325485],"study_design_scores_gemma":[0.0000330147,0.0006331836,0.005499463,0.00000805064,0.000037431,0.000249733,0.00002113221,0.002628949,0.9892542,0.00004958131,0.001580205,0.000004988388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930419,0.002582033,0.003100621,0.0001520317,0.00002597217,0.00001611714,0.00009968418,0.00005163781,0.0009300581],"genre_scores_gemma":[0.9974394,0.0008777294,0.0008726464,0.00004725271,0.000007025571,0.000006900443,0.00008390857,0.000004551186,0.0006604533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266409,"threshold_uncertainty_score":0.004236579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00924953450286622,"score_gpt":0.2134386589213577,"score_spread":0.2041891244184915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}