{"id":"W4390799616","doi":"10.1002/9781119660699.ch15","title":"Pharmacokinetic Behaviors of Orally Administered Drugs","year":2023,"lang":"en","type":"other","venue":"","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Pharmacokinetics; Pharmacology; Disposition; Oral administration; Drug; Absorption (acoustics); Distribution (mathematics); Medicine; Physiologically based pharmacokinetic modelling; Chemistry; Psychology; Mathematics; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005407517,0.0004722804,0.0007995631,0.000422497,0.00006003835,0.00001375969,0.0005686693,0.001094955,0.04166623],"category_scores_gemma":[0.00003094476,0.0004540993,0.0002882895,0.0003498871,0.0003006732,0.00004252225,0.0001600753,0.0007522058,0.004180653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004747786,"about_ca_system_score_gemma":0.0001389987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006177138,"about_ca_topic_score_gemma":0.0004080784,"domain_scores_codex":[0.9975232,0.0004137637,0.0006969872,0.0005160292,0.0003307617,0.0005192447],"domain_scores_gemma":[0.998441,0.0002623187,0.0004948348,0.0004340547,0.00007291163,0.0002948444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001198309,0.0003265812,0.000759907,0.0004128259,0.0004778327,0.00008603364,0.0003836703,0.00001253088,0.000756504,0.0003967875,0.9865693,0.009698169],"study_design_scores_gemma":[0.001422912,0.0001228454,0.00005905068,0.0001396558,0.0005040727,0.00001020322,0.0001737668,0.0001156251,0.00203072,0.0000216893,0.9949291,0.0004703935],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.001774399,0.001019705,0.00001963649,0.0001917377,0.006641242,0.0009604412,0.0007313183,0.001644009,0.9870175],"genre_scores_gemma":[0.04324411,0.0007566617,0.00007977349,0.0006517926,0.0005996994,0.00008641832,0.00007927114,0.001011647,0.9534906],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.04146971,"threshold_uncertainty_score":0.9997911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1315947690068014,"score_gpt":0.4575039184186885,"score_spread":0.325909149411887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}