{"id":"W4390806091","doi":"10.1016/j.chom.2023.12.013","title":"Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course","year":2024,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; Hospital for Sick Children; University of Ottawa","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Complementary and Integrative Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Deutsche Forschungsgemeinschaft; Crohn's and Colitis Foundation; University of Ottawa; National Institutes of Health; California Department of Fish and Game","keywords":"Metabolomics; Biology; Metabolite; Microbiome; Inflammatory bowel disease; Ulcerative colitis; Metabolome; Microbiology; Disease; Biochemistry; Internal medicine; Bioinformatics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000149623,0.0002631324,0.0004094351,0.0007488538,0.0001983636,0.0007027622,0.0001481105,0.0004061888,0.001510063],"category_scores_gemma":[0.0005156356,0.0002158086,0.0002598148,0.000805862,0.0002103876,0.0002669213,0.0002815685,0.0005428538,0.0002517291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001669169,"about_ca_system_score_gemma":0.0001442527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005388057,"about_ca_topic_score_gemma":0.0007887032,"domain_scores_codex":[0.9997966,0.00004754382,0.00001268076,0.00005877903,0.00003113774,0.00005339783],"domain_scores_gemma":[0.9997054,0.00007152452,0.0001238622,0.00002081147,0.00002306585,0.0000552793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003778678,0.0001938516,0.5748981,0.00008964193,0.000214162,0.0005892038,0.0001903947,0.0003288152,0.3986717,0.0001731904,0.0002818317,0.02059053],"study_design_scores_gemma":[0.00001794747,0.0002972091,0.9770039,0.00001436724,0.00009258593,0.0005239953,0.0002606223,0.0009670018,0.01999487,0.0003514489,0.0004654556,0.00001068702],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998018,0.0004624566,0.0005967555,0.00006224244,0.00000873036,0.000005537919,0.000444465,0.000019262,0.0003824739],"genre_scores_gemma":[0.9986601,0.0001507082,0.0005672167,0.00004922,0.000009984612,0.000008124853,0.0002347179,0.000009593432,0.0003103872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510063,"threshold_uncertainty_score":0.005051613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379236241904793,"score_gpt":0.2854850204437493,"score_spread":0.2716926580247014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}