{"id":"W4390806383","doi":"10.1016/j.expneurol.2024.114688","title":"PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation","year":2024,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Science Foundation of Chongqing; Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission; National Natural Science Foundation of China","keywords":"Proprotein convertase; Kexin; Gene knockdown; Amyloid precursor protein secretase; Biology; Proprotein Convertases; Furin; HEK 293 cells; Amyloid precursor protein; Alzheimer's disease; Neuroscience; Genetics; Medicine; Disease; Pathology; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009810922,0.00026103,0.0002387689,0.0001148886,0.0001399798,0.00007234191,0.00008867498,0.00009242397,0.0005950386],"category_scores_gemma":[0.00002866396,0.0002189239,0.0001535036,0.0001744931,0.000129592,0.0001821113,0.00009331703,0.000212025,0.0004947124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004105504,"about_ca_system_score_gemma":0.0001400911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002561856,"about_ca_topic_score_gemma":5.653765e-7,"domain_scores_codex":[0.9981365,0.0001848686,0.0002487998,0.0006231041,0.000333238,0.0004735331],"domain_scores_gemma":[0.9989679,0.00008318139,0.00003711486,0.0002818917,0.00002986619,0.0006000149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01261564,0.008455542,0.04850801,0.0005111741,0.01709247,0.02753227,0.002281201,0.00001036659,0.7935628,0.001308462,0.05919342,0.02892865],"study_design_scores_gemma":[0.007297944,0.008730805,0.06479122,0.0003047643,0.002518468,0.001349674,0.0004248468,0.02338582,0.8604719,0.0005497964,0.02863034,0.001544397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8555709,0.1394561,0.000008396612,0.002821767,0.0003423186,0.0007909357,0.00008967148,0.0003258611,0.000594034],"genre_scores_gemma":[0.9979649,0.0001635119,0.00004894019,0.0007734136,0.0002268153,0.0002676187,0.0004068146,0.00007002193,0.00007796734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.142394,"threshold_uncertainty_score":0.8927459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219027407850246,"score_gpt":0.3181252359921341,"score_spread":0.2962224952071095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}