{"id":"W4390819889","doi":"10.1021/acs.bioconjchem.3c00522","title":"Palladium-Mediated <i>S</i>-Arylation of Cysteine Residues with 4-[<sup>18</sup>F]Fluoroiodobenzene ([<sup>18</sup>F]FIB)","year":2024,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; LNCaP; Bioconjugation; Peptidomimetic; Radioligand; Cysteine; Combinatorial chemistry; Prostate cancer; Biochemistry; Peptide; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003082418,0.0009170059,0.0008417736,0.00008672404,0.0002706107,0.0002129847,0.0008721115,0.0008054776,0.00687068],"category_scores_gemma":[0.000225688,0.0008685683,0.0003667135,0.0008353693,0.0004873533,0.0002936677,0.0002489183,0.0008575451,0.0002127719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002674552,"about_ca_system_score_gemma":0.0004054412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001471614,"about_ca_topic_score_gemma":0.000006670069,"domain_scores_codex":[0.9954981,0.00002983656,0.001270413,0.001495291,0.0007980753,0.0009083138],"domain_scores_gemma":[0.9965825,0.0004435049,0.000484758,0.001655937,0.0003303531,0.0005029639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000231029,0.0002732094,0.0007718512,0.003897134,0.0003559838,0.00008695959,0.0004182544,0.0008292481,0.9821638,0.00006789781,0.01015887,0.0007457446],"study_design_scores_gemma":[0.001381628,0.00004830064,0.00003603533,0.001072888,0.0002555107,0.0001466597,0.0007361246,0.00399354,0.9310176,0.0002119275,0.06016335,0.0009364909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9357144,0.002612219,0.0000925034,0.0007827276,0.00003128187,0.0003761604,0.001248066,0.0009389333,0.05820374],"genre_scores_gemma":[0.9821488,0.0004131978,0.0004714887,0.00009610924,0.001064512,0.0003400509,0.003169464,0.0001993787,0.012097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05114627,"threshold_uncertainty_score":0.9993765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627803911795779,"score_gpt":0.2438493304065425,"score_spread":0.2275712912885847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}