{"id":"W4390825876","doi":"10.1186/s13195-024-01383-1","title":"Diagnostic accuracy of research criteria for prodromal frontotemporal dementia","year":2024,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Western University; Occupational Cancer Research Centre; Health Sciences Centre; Montreal Neurological Institute and Hospital; University of Toronto; Sunnybrook Health Science Centre; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Canadian Institutes of Health Research; Associazione Italiana Ricerca Alzheimer; Stockholms Läns Landsting; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; UK Dementia Research Institute; Fondazione Cariplo; Vetenskapsrådet; Fondation pour la Recherche sur Alzheimer; Ministero della Salute; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; ZonMw; Weston Brain Institute; Alzheimer's Drug Discovery Foundation; Brain Research UK; Deutsche Forschungsgemeinschaft; Stichting Dioraphte; University of Cambridge; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Alzheimer Nederland; EU Joint Programme – Neurodegenerative Disease Research; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Association","keywords":"Frontotemporal dementia; Atrophy; Internal medicine; Medicine; Dementia; Cohort; Oncology; Psychology; Psychiatry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009006799,0.0008711814,0.0006884345,0.003911206,0.0004990698,0.001127276,0.001057171,0.001052356,0.001343637],"category_scores_gemma":[0.03194802,0.0002505126,0.0007929588,0.0005939784,0.0005370596,0.0007282159,0.001177377,0.0006493407,0.0005906335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005912867,"about_ca_system_score_gemma":0.000468508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001873574,"about_ca_topic_score_gemma":0.003052736,"domain_scores_codex":[0.9960453,0.001699112,0.0005923439,0.0005759163,0.0008436673,0.0002436217],"domain_scores_gemma":[0.9814413,0.007687743,0.005092528,0.001072431,0.003553531,0.001152487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008116665,0.00008773882,0.9847212,0.00005607647,0.0001822615,0.000107133,0.0001302805,0.0003292235,0.0006604374,0.0001023912,0.0004994465,0.012312],"study_design_scores_gemma":[0.00009603296,0.0005757413,0.9900705,0.00009503741,0.0001731254,0.001280891,0.0002075978,0.005637289,0.0007739662,0.0004623252,0.0006043438,0.00002322001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938473,0.001978354,0.001124896,0.0001802001,0.00006298687,0.00008587662,0.0004853953,0.0000489921,0.002185843],"genre_scores_gemma":[0.9977035,0.0001254607,0.001413395,0.00003083039,0.00002410317,0.00003429435,0.0005735544,0.000005326245,0.00008953766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009006799,"threshold_uncertainty_score":0.04763305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3533920116111081,"score_gpt":0.5298283425132517,"score_spread":0.1764363309021436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}