{"id":"W4390828005","doi":"10.1101/2024.01.10.574913","title":"Internal regulation between constitutively expressed T cell coinhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"BTLA; Biology; Receptor; CD5; T cell; Cell biology; CD8; Signal transduction; T-cell receptor; Immunology; Immune system; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322428,0.0001754834,0.0001921165,0.0002341175,0.0001156073,0.0003592304,0.000215191,0.0002615611,0.001100974],"category_scores_gemma":[0.0001380234,0.0001241736,0.0001652973,0.00009982527,0.0002160677,0.0002035071,0.000339784,0.0006481981,0.0002554271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002204159,"about_ca_system_score_gemma":0.00005078981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001617937,"about_ca_topic_score_gemma":0.0002707898,"domain_scores_codex":[0.9997754,0.00003826509,0.00002290756,0.00004888036,0.00004673449,0.00006785286],"domain_scores_gemma":[0.9996707,0.00005748602,0.0001057941,0.00003391265,0.00003148196,0.0001006147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000435745,0.000008118401,0.0002789668,0.000006546158,0.000001187772,0.00003142249,0.000007369048,0.000008566876,0.9993585,0.00003070053,0.000004275262,0.0002208081],"study_design_scores_gemma":[0.00001550103,0.0003362192,0.02704808,0.000008906872,0.00001666203,0.0005546067,0.0001188829,0.0006645026,0.9698439,0.00004102842,0.001346304,0.000005530344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982273,0.0005590113,0.000711559,0.00001890998,0.000006717351,0.00000480547,0.00006457441,0.00002062331,0.0003866685],"genre_scores_gemma":[0.9980002,0.0001249822,0.0003908988,0.00002427817,0.00000443954,0.0000117081,0.00012734,0.000009758613,0.001306463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100974,"threshold_uncertainty_score":0.00368315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108171004748709,"score_gpt":0.2091746721028322,"score_spread":0.1983575716279614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}