{"id":"W4390838396","doi":"10.1101/2024.01.12.24301197","title":"Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammation","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); Terry Fox Research Institute; University of British Columbia","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministerie van Volksgezondheid, Welzijn en Sport; HORIZON EUROPE Framework Programme; Rijksuniversiteit Groningen; Universitair Medisch Centrum Groningen; European Commission","keywords":"Immune system; Immunology; Microbiome; Rhinovirus; Biology; Antibody; Inflammation; Population; Cytomegalovirus; Systemic inflammation; Epitope; Virology; Virus; Medicine; Viral disease; Genetics; Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007254657,0.0003984723,0.0005135836,0.0006106217,0.0004912394,0.0009830929,0.0002950142,0.0005787726,0.003775863],"category_scores_gemma":[0.00199195,0.0002252743,0.0004682493,0.00070904,0.0002813967,0.0004643383,0.0006586052,0.0006759266,0.0005167683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002413172,"about_ca_system_score_gemma":0.000230226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002569416,"about_ca_topic_score_gemma":0.003660246,"domain_scores_codex":[0.9994962,0.000116331,0.00004231293,0.0001935005,0.00006553467,0.00008605535],"domain_scores_gemma":[0.9992388,0.0001398916,0.00027716,0.000104849,0.0001622231,0.00007702631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006527975,0.00008068646,0.9483609,0.000375708,0.0004645262,0.0001541673,0.0005970095,0.0003105454,0.02452566,0.0002780373,0.001298032,0.02290178],"study_design_scores_gemma":[0.000008398954,0.0002149738,0.9912452,0.00008163827,0.0001997316,0.0006055806,0.0004494608,0.000500355,0.002472692,0.0006881802,0.003512935,0.00002077941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870899,0.005162374,0.002525972,0.0001684443,0.00005372613,0.00002391885,0.003300074,0.00003643876,0.001639064],"genre_scores_gemma":[0.9953547,0.0008019654,0.00116045,0.0001579903,0.00003910024,0.00003605953,0.001218622,0.00001937305,0.001211797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003775863,"threshold_uncertainty_score":0.01263154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187418000894618,"score_gpt":0.329783414324249,"score_spread":0.3079092343153028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}