{"id":"W4390885974","doi":"10.3390/biom14010111","title":"Lymphocyte-Specific Protein 1 Regulates Expression and Stability of Endothelial Nitric Oxide Synthase","year":2024,"lang":"en","type":"article","venue":"Biomolecules","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Enos; Downregulation and upregulation; Nitric oxide; Nitric Oxide Synthase Type III; Cell biology; Biology; Nitric oxide synthase; Gene knockdown; Endothelial nitric oxide synthase; Internal medicine; Endocrinology; Chemistry; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008361005,0.0002306879,0.0001652368,0.0001596376,0.0001667195,0.0002794357,0.0001106463,0.0001768293,0.00102827],"category_scores_gemma":[0.0001336834,0.00007991894,0.0001481616,0.00008312512,0.000146237,0.0001521818,0.0002397897,0.0004096944,0.0002254215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057573,"about_ca_system_score_gemma":0.0001192498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001693747,"about_ca_topic_score_gemma":0.0002652275,"domain_scores_codex":[0.9999162,0.00001542441,0.000004933795,0.00002526824,0.00001386456,0.00002442134],"domain_scores_gemma":[0.9999357,0.000009139771,0.00002241431,0.000004151853,0.00000739259,0.00002115619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001377451,0.00002442993,0.0006793204,0.00003448344,0.00000476671,0.00007160244,0.00001355388,0.00005137316,0.9967207,0.0001180996,0.00007889017,0.002065093],"study_design_scores_gemma":[0.00003348038,0.0002762229,0.0509645,0.00001534798,0.00003322386,0.0004663247,0.00007597347,0.001883101,0.941267,0.0002581405,0.00471507,0.00001162207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934321,0.002948406,0.002019227,0.0001666959,0.00003747591,0.000007530769,0.0002133681,0.00007835345,0.001097031],"genre_scores_gemma":[0.9963371,0.001024881,0.0007355883,0.00005896068,0.000009484739,0.00001379974,0.0002523998,0.00001044759,0.001557453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102827,"threshold_uncertainty_score":0.003439903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657128458363695,"score_gpt":0.2541702487659052,"score_spread":0.2375989641822682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}