{"id":"W4390904533","doi":"10.1523/jneurosci.1560-23.2024","title":"Amnesia after repeated head impact is caused by impaired synaptic plasticity in the memory engram","year":2024,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Traumatic Brain Injury Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Georgetown University","keywords":"Engram; Neuroscience; Synaptic plasticity; Retrograde amnesia; Neuroplasticity; Hippocampal formation; Psychology; Hippocampus; Memory consolidation; Amnesia; Biology; Cognitive psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009552306,0.0007429078,0.000379545,0.0003794857,0.0001082749,0.0002110736,0.0002676813,0.0003524894,0.00138745],"category_scores_gemma":[0.0001144944,0.0001993923,0.0003472864,0.0001637972,0.0004279842,0.0002244773,0.0004394226,0.0009000602,0.0002692216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002024363,"about_ca_system_score_gemma":0.0001617304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008576224,"about_ca_topic_score_gemma":0.0009245296,"domain_scores_codex":[0.9998733,0.000007938329,0.00001387958,0.00002870739,0.00003856332,0.00003764602],"domain_scores_gemma":[0.9998201,0.00001160102,0.00008976527,0.00002758637,0.00001227013,0.0000387447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009783167,0.00002804689,0.0003789034,0.00002941633,0.000009503377,0.0001862109,0.00002033281,0.00002316179,0.9980168,0.00002918797,0.00001894541,0.001161647],"study_design_scores_gemma":[0.00001491834,0.0009676259,0.0376958,0.00001199976,0.00005538276,0.001467056,0.00005615446,0.0003275113,0.9584976,0.0001053174,0.0007910712,0.000009520341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965156,0.0008237011,0.001642754,0.00004221379,0.00001929944,0.00001888735,0.0002390612,0.0001660534,0.000532422],"genre_scores_gemma":[0.9960737,0.0006761608,0.0009274934,0.00004713013,0.00000930859,0.00003419161,0.0002623451,0.00002362865,0.001946112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00138745,"threshold_uncertainty_score":0.004641473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632728073699001,"score_gpt":0.3788513033170484,"score_spread":0.3125240225800583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}