{"id":"W4390906723","doi":"10.1101/2024.01.15.24301335","title":"Beyond Hypertension: Examining Variable Blood Pressure’s Role in Cognition and Brain Structure","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Carleton University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Alzheimer's Association","keywords":"Neuropathology; Dementia; Hyperintensity; Cognitive decline; White matter; Cognition; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Cohort; Blood pressure; Brain Structure and Function; Psychology; Brain size; Cardiology; Internal medicine; Medicine; Gerontology; Disease; Magnetic resonance imaging; Neuroscience; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001565774,0.0004177311,0.0003440233,0.0006326064,0.0004115537,0.0006639279,0.0005848327,0.0005679682,0.001012678],"category_scores_gemma":[0.003762018,0.0001520419,0.0006097038,0.0008760836,0.0005540681,0.0008363398,0.0004354228,0.0005556566,0.00007590614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273048,"about_ca_system_score_gemma":0.0004648077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004152312,"about_ca_topic_score_gemma":0.009561052,"domain_scores_codex":[0.9995306,0.0001996372,0.00003411229,0.0001012785,0.00008091819,0.00005359998],"domain_scores_gemma":[0.9979756,0.0007086319,0.0006926002,0.000190577,0.0001781975,0.0002543489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007654386,0.00009633382,0.9839541,0.0001317884,0.000617258,0.0001111957,0.0003007733,0.0001001991,0.0006705514,0.0001252383,0.0002572248,0.01286986],"study_design_scores_gemma":[0.00001897116,0.0004522663,0.9980033,0.00002492107,0.0002346745,0.00009249547,0.0001284312,0.0003375024,0.0001421958,0.0003018817,0.0002590292,0.000004354378],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938877,0.004108632,0.0005609462,0.0002635506,0.00003288661,0.00001475007,0.0002709324,0.000006628486,0.0008538705],"genre_scores_gemma":[0.9989748,0.0004056727,0.0002868676,0.00005070239,0.00004662588,0.000008249058,0.00008983276,0.000001701432,0.0001355211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004152312,"threshold_uncertainty_score":0.008280694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822990676607004,"score_gpt":0.2749976423669344,"score_spread":0.2567677356008643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}