{"id":"W4390908319","doi":"10.1101/2024.01.16.575809","title":"Spatiotemporal visualization of DNA replication by click chemistry reveals bubbling of viral DNA in virion formation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Kanton Zürich; National Science Foundation","keywords":"Chromatin; Biology; DNA; DNA replication; Cell biology; Viral replication; RNA; Scaffold/matrix attachment region; DNA replication factor CDT1; Control of chromosome duplication; Molecular biology; Genetics; Virus; Gene; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002001484,0.0002743346,0.0001105237,0.0002064794,0.0001336159,0.0003771578,0.0002101103,0.0003157215,0.001711241],"category_scores_gemma":[0.0001357726,0.0001762393,0.0001431871,0.000115179,0.0002977813,0.000310198,0.0002707748,0.0003731818,0.0003533877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328542,"about_ca_system_score_gemma":0.000179907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004901824,"about_ca_topic_score_gemma":0.0003788858,"domain_scores_codex":[0.999916,0.000009164929,0.00000347141,0.00002690251,0.00002199987,0.00002240034],"domain_scores_gemma":[0.9999222,0.000022303,0.00001861508,0.000007166946,0.000007465932,0.00002223251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001883493,0.00000320269,0.00004918797,0.000008488377,9.465591e-7,0.00002156455,0.00001003171,0.00003312749,0.9993636,0.0001415314,0.00001669642,0.0003328753],"study_design_scores_gemma":[0.000003951136,0.00002582208,0.000549331,0.00000116335,0.000001438637,0.00006323379,0.000005995932,0.001131199,0.9977119,0.00003834285,0.0004651209,0.000002568644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984989,0.0004370722,0.0120726,0.0001028112,0.0000213665,0.00001859674,0.0001622925,0.0001977036,0.001998507],"genre_scores_gemma":[0.9884061,0.0002959272,0.007499408,0.00003709988,0.000007300496,0.00002389425,0.0001486051,0.0000415487,0.003540104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711241,"threshold_uncertainty_score":0.005724728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499313315319691,"score_gpt":0.2834901105049812,"score_spread":0.2684969773517843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}