{"id":"W4390910879","doi":"10.7554/elife.90274.3","title":"Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact","funders":"Japan Science and Technology Agency; Waksman Foundation of Japan; National Health and Medical Research Council; Japan Society for the Promotion of Science; Sumitomo Foundation; Tokyo Biochemical Research Foundation; Australian Research Council; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Shinnihon Foundation of Advanced Medical Treatment Research; Uehara Memorial Foundation; Japan Agency for Medical Research and Development; Naito Foundation","keywords":"Bacterial outer membrane; Membrane; Biology; Inner membrane; Outer membrane efflux proteins; Cell biology; Folding (DSP implementation); Membrane protein; Biophysics; Biochemistry; Membrane transport protein; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001890157,0.0003215843,0.0003119998,0.0001260487,0.0001534014,0.0004119347,0.0002958809,0.0003729927,0.001753351],"category_scores_gemma":[0.0001965804,0.00017742,0.000219709,0.0001044179,0.000314918,0.0003401576,0.0005573194,0.0008351913,0.0008107094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003515507,"about_ca_system_score_gemma":0.0002297101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000188004,"about_ca_topic_score_gemma":0.0003280831,"domain_scores_codex":[0.999757,0.00002692195,0.00001359552,0.00006212428,0.00007079952,0.00006954896],"domain_scores_gemma":[0.9998351,0.00002075385,0.0000404336,0.000017124,0.00002249288,0.00006408495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007800024,0.00001552189,0.00006451209,0.00001736399,0.000001303553,0.00002025391,0.000004357871,0.00002692895,0.9989895,0.0001028006,0.0000267023,0.0006526858],"study_design_scores_gemma":[0.000008754666,0.00007408603,0.000501077,0.000002282028,0.00000278367,0.00006912239,0.00001052574,0.000504271,0.9977271,0.00003762046,0.001059535,0.000002855096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905194,0.001051422,0.006229597,0.0002449521,0.00006850011,0.00001299112,0.00009979719,0.0001112753,0.001662048],"genre_scores_gemma":[0.988021,0.0003613172,0.007490358,0.0001354407,0.00001605767,0.00001601511,0.0001740477,0.00004236391,0.003743578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001753351,"threshold_uncertainty_score":0.005865574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660241175262807,"score_gpt":0.2538383029490987,"score_spread":0.2372358911964706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}