{"id":"W4390918478","doi":"10.1101/2024.01.15.575749","title":"Bacterial ADP-heptose initiates a revival stem cell program in the intestinal epithelium","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Vector Institute; University of Toronto","funders":"","keywords":"Biology; Stem cell; Paneth cell; Cell biology; Organoid; Crypt; Intestinal epithelium; Epithelium; Progenitor cell; Intestinal mucosa; Necroptosis; Apoptosis; Programmed cell death; Biochemistry; Internal medicine; Endocrinology; Genetics; Small intestine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018027,0.0001952492,0.000255431,0.0001845368,0.0001172727,0.0003516052,0.00008645404,0.0002039496,0.001367855],"category_scores_gemma":[0.00008412357,0.0001227559,0.0002742112,0.0001059473,0.0001989662,0.0001864647,0.0003663808,0.0005066709,0.0004430444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001767337,"about_ca_system_score_gemma":0.000128156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002225899,"about_ca_topic_score_gemma":0.0003515718,"domain_scores_codex":[0.9998726,0.00001232492,0.00001083351,0.00003194321,0.00004272045,0.00002958934],"domain_scores_gemma":[0.9998908,0.0000130223,0.0000307537,0.00001327593,0.00001830168,0.00003377066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005331698,0.000004944367,0.0002991823,0.00003004239,0.000001871855,0.0000543299,0.00001188588,0.00002602636,0.998916,0.00004891974,0.00001679182,0.0005366632],"study_design_scores_gemma":[0.000005315393,0.0002012639,0.01600601,0.00001015975,0.00000776709,0.0002231484,0.0001151842,0.0009707946,0.9797286,0.00007003192,0.002656851,0.000004710143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990121,0.001063126,0.006066836,0.00008550921,0.00003277266,0.00003623762,0.0009548848,0.0001533748,0.001486208],"genre_scores_gemma":[0.9934713,0.0004247196,0.002608418,0.00007985582,0.000007614393,0.00002976587,0.0009414876,0.0000300311,0.002406968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367855,"threshold_uncertainty_score":0.004575968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386016380245695,"score_gpt":0.2591309216123035,"score_spread":0.2352707578098465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}