{"id":"W4390919528","doi":"10.1093/brain/awae013","title":"Imaging chronic active lesions in multiple sclerosis: a consensus statement","year":2024,"lang":"en","type":"review","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; International Collaboration On Repair Discoveries; St. Michael's Hospital; University of Toronto; NeuroRx Research (Canada)","funders":"Janssen Pharmaceuticals; National Institute of Biomedical Imaging and Bioengineering; Principia Biopharma; Perelman School of Medicine, University of Pennsylvania; EMD Serono; Fondazione Regionale per la Ricerca Biomedica; Idorsia Pharmaceuticals; Multiple Sclerosis Society of Canada; Atara Biotherapeutics; Genentech; International Progressive MS Alliance; National Multiple Sclerosis Society; Horizon Therapeutics; Myelin Repair Foundation; Centre d'Imagerie BioMédicale; University at Buffalo; Fondation Brain Canada; Fondazione Cariplo; Multiple Sclerosis Society; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; National Institute on Drug Abuse; University of Pennsylvania; Natural Sciences and Engineering Research Council of Canada; Biogen; National Center for Advancing Translational Sciences; Craig H. Neilsen Foundation; Eli Lilly and Company; U.S. Department of Defense; Conrad N. Hilton Foundation; Sanofi; U.S. Department of Veterans Affairs; National Institute of Nursing Research; National Institute of Mental Health; Patient-Centered Outcomes Research Institute; National Institutes of Health; International Collaboration on Repair Discoveries","keywords":"Multiple sclerosis; Consensus conference; Medicine; Statement (logic); Pathology; Psychiatry; Internal medicine; Political science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0130394,0.001434125,0.003454789,0.005664078,0.0007907859,0.002477147,0.004314082,0.005965232,0.002775041],"category_scores_gemma":[0.01071951,0.0007238094,0.003401348,0.004785267,0.001438603,0.003595648,0.002601678,0.00590441,0.002214115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002499228,"about_ca_system_score_gemma":0.01041578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003149666,"about_ca_topic_score_gemma":0.003729118,"domain_scores_codex":[0.9955752,0.001094393,0.001554687,0.0003551655,0.001190465,0.0002300674],"domain_scores_gemma":[0.9892953,0.003774733,0.001432359,0.0002141588,0.004708327,0.0005750217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001884051,0.0001359219,0.0005857483,0.05663379,0.0003341857,0.0003757592,0.000269442,0.0004836996,0.0009980242,0.007237852,0.2945224,0.6382348],"study_design_scores_gemma":[0.00008230498,0.0001042525,0.001413337,0.06382065,0.0006016582,0.001322625,0.0002157317,0.0001356522,0.000318033,0.004841403,0.9270901,0.00005431815],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001863347,0.9649373,0.00104641,0.02510355,0.006712583,0.0001605636,0.0002901969,0.00003330821,0.001529826],"genre_scores_gemma":[0.001786214,0.9733552,0.004741793,0.01370717,0.003431931,0.0002877464,0.0009435615,0.00001546078,0.001730913],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0130394,"threshold_uncertainty_score":0.06895971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2343564767531432,"score_gpt":0.427102443011925,"score_spread":0.1927459662587818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}