{"id":"W4390919528","doi":"10.1093/brain/awae013","title":"Imaging chronic active lesions in multiple sclerosis: a consensus statement","year":2024,"lang":"en","type":"review","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; International Collaboration On Repair Discoveries; St. Michael's Hospital; University of Toronto; NeuroRx Research (Canada)","funders":"Janssen Pharmaceuticals; National Institute of Biomedical Imaging and Bioengineering; Principia Biopharma; Perelman School of Medicine, University of Pennsylvania; EMD Serono; Fondazione Regionale per la Ricerca Biomedica; Idorsia Pharmaceuticals; Multiple Sclerosis Society of Canada; Atara Biotherapeutics; Genentech; International Progressive MS Alliance; National Multiple Sclerosis Society; Horizon Therapeutics; Myelin Repair Foundation; Centre d'Imagerie BioMédicale; University at Buffalo; Fondation Brain Canada; Fondazione Cariplo; Multiple Sclerosis Society; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; National Institute on Drug Abuse; University of Pennsylvania; Natural Sciences and Engineering Research Council of Canada; Biogen; National Center for Advancing Translational Sciences; Craig H. Neilsen Foundation; Eli Lilly and Company; U.S. Department of Defense; Conrad N. Hilton Foundation; Sanofi; U.S. Department of Veterans Affairs; National Institute of Nursing Research; National Institute of Mental Health; Patient-Centered Outcomes Research Institute; National Institutes of Health; International Collaboration on Repair Discoveries","keywords":"Multiple sclerosis; Consensus conference; Medicine; Statement (logic); Pathology; Psychiatry; Internal medicine; Political science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007766191,0.000596604,0.002040046,0.0008196004,0.0001176352,0.00006249162,0.0002165243,0.0001632666,0.0001311244],"category_scores_gemma":[0.001981196,0.0004402351,0.0005707553,0.0008033568,0.0002602811,0.0000401021,0.0005086619,0.001228321,0.0006227072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002293139,"about_ca_system_score_gemma":0.001655346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003063034,"about_ca_topic_score_gemma":0.0006036663,"domain_scores_codex":[0.9963445,0.0003855394,0.0009641403,0.0008783895,0.0005972575,0.0008301642],"domain_scores_gemma":[0.9976379,0.001241159,0.0001891965,0.0005921644,0.00009424218,0.0002453584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002222061,0.0001209739,0.00001253752,0.02343928,0.0004226163,0.0002402657,0.0002397367,6.447484e-7,0.00004914179,0.00001491771,0.044576,0.9308617],"study_design_scores_gemma":[0.001280248,0.00007784636,0.0003822332,0.09303296,0.0005238046,0.00003194188,0.0002770555,0.0002374398,0.000006027192,0.000008125318,0.903805,0.0003372834],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004617733,0.9925161,0.000005838033,0.002492875,0.0002309819,0.00335969,0.0004260174,0.0001408165,0.0007814931],"genre_scores_gemma":[0.0004334745,0.9959921,0.0002152896,0.000113407,0.0003143192,0.001276382,0.0001776376,0.0001321116,0.001345342],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9305244,"threshold_uncertainty_score":0.9998049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2343564767531432,"score_gpt":0.427102443011925,"score_spread":0.1927459662587818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}