{"id":"W4390920137","doi":"10.1016/j.ejpb.2024.114180","title":"Development of an immunosuppressed orthotopic hepatocellular carcinoma rat model for the evaluation of chemo- and radioembolization therapies","year":2024,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Lundbeckfonden; H. Lundbeck A/S; Canada Foundation for Innovation","keywords":"Hepatocellular carcinoma; Medicine; Fibrosis; Histology; Pathology; Tolerability; Liver cancer; Bioluminescence imaging; Tumor progression; Cancer research; Internal medicine; Urology; Oncology; Cancer; Adverse effect; Biology; Transfection; Cell culture; Luciferase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004963533,0.001211076,0.0008039522,0.001371589,0.0003592685,0.0004147996,0.0005375151,0.0006158647,0.002629858],"category_scores_gemma":[0.0001596992,0.0002997972,0.0005916294,0.0005016694,0.0004400743,0.0006424736,0.0003459067,0.001716511,0.0008743281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003662804,"about_ca_system_score_gemma":0.0004897061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008536226,"about_ca_topic_score_gemma":0.001449838,"domain_scores_codex":[0.9995529,0.00004821441,0.00005451479,0.00009298428,0.0001310854,0.0001202498],"domain_scores_gemma":[0.9995108,0.00004918879,0.0001268244,0.00008849238,0.00007997892,0.0001448451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005318255,0.0007666457,0.0004493275,0.00005393362,0.00001046721,0.0001133355,0.00005256165,0.0001658785,0.995757,0.0001734777,0.00007961824,0.001845909],"study_design_scores_gemma":[0.00005556664,0.005355945,0.003177,0.00001289942,0.00005051335,0.0002955114,0.00007265727,0.001452757,0.987667,0.00006884768,0.001773313,0.00001807045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812905,0.001184541,0.01186941,0.0002154428,0.0001659979,0.0004466642,0.001593903,0.0003678903,0.002865681],"genre_scores_gemma":[0.9495313,0.002943256,0.02659875,0.0001973217,0.00007936316,0.001580826,0.002778982,0.0001399426,0.01615024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002629858,"threshold_uncertainty_score":0.008797705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1984028718162717,"score_gpt":0.3567945819787292,"score_spread":0.1583917101624575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}