{"id":"W4390933271","doi":"10.25251/skin.8.supp.309","title":"Investigator- and Patient-Rated Local Tolerability in Phase 3 Trials of Topical Roflumilast in Patients With Psoriasis, Seborrheic Dermatitis, and Atopic Dermatitis","year":2024,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dermatrials Research; Probity Medical Research; Queen's University","funders":"","keywords":"Tolerability; Dermatology; Medicine; Atopic dermatitis; Roflumilast; Dermis; Seborrheic dermatitis; Psoriasis; Erythema; Transepidermal water loss; Stratum corneum; Adverse effect; Pharmacology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006864948,0.001215094,0.002046556,0.0004741518,0.0007032037,0.001025557,0.0006818349,0.001106538,0.003432781],"category_scores_gemma":[0.005265301,0.0007227479,0.002675314,0.0005664085,0.000656558,0.001102442,0.0004021993,0.002759771,0.0005626989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007884665,"about_ca_system_score_gemma":0.001176978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007068134,"about_ca_topic_score_gemma":0.002617014,"domain_scores_codex":[0.9968044,0.002126937,0.0002722857,0.0002295812,0.0003166653,0.0002502264],"domain_scores_gemma":[0.9957415,0.001636985,0.001384848,0.0001904419,0.0003661526,0.0006800161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8760355,0.02084158,0.01844904,0.001225688,0.003266971,0.000191389,0.0003963955,0.001021463,0.0116798,0.00009184817,0.00245251,0.06434786],"study_design_scores_gemma":[0.5738901,0.3708878,0.04849933,0.0000840521,0.001348547,0.0002717577,0.0001349865,0.0009279864,0.00175394,0.0001320275,0.002011824,0.00005763515],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847214,0.007656141,0.0004980271,0.000412981,0.0001227381,0.003756629,0.0009312707,0.00004990681,0.001850821],"genre_scores_gemma":[0.9907262,0.00220379,0.0008505499,0.0006148587,0.0001666884,0.003873619,0.0007723001,0.00001545855,0.0007765085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006864948,"threshold_uncertainty_score":0.03630579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100810104001265,"score_gpt":0.2751572988929927,"score_spread":0.2641491978529801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}