{"id":"W4390933424","doi":"10.1158/1538-7445.panca2023-c109","title":"Abstract C109: Nanostring-based subtyping of pancreatic ductal adenocarcinoma is strongly influenced by the stromal compartment","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Vancouver General Hospital; Pancreas Centre (Canada)","funders":"","keywords":"Subtyping; Stroma; Stromal cell; Adenocarcinoma; Pancreatic cancer; Oncology; Pancreatic ductal adenocarcinoma; Cancer research; Biology; Pathology; Internal medicine; Medicine; Cancer; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008765006,0.000237404,0.0003332311,0.0007013776,0.0003359802,0.0008841821,0.0002450933,0.0002738934,0.002038659],"category_scores_gemma":[0.001758872,0.0001265619,0.0002831762,0.0006631059,0.0003248233,0.0002338873,0.0005918189,0.0003106277,0.0006164349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003425269,"about_ca_system_score_gemma":0.0002897987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001644165,"about_ca_topic_score_gemma":0.002859208,"domain_scores_codex":[0.9993395,0.0001012323,0.00007839813,0.0002310884,0.0001796724,0.0000700661],"domain_scores_gemma":[0.9989563,0.0003178987,0.0002678418,0.0001363385,0.0002021487,0.0001193666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001433749,0.00004847286,0.7844069,0.0002878285,0.0002719788,0.0004437386,0.0001619872,0.001212941,0.1828954,0.0002317222,0.00230122,0.02630411],"study_design_scores_gemma":[0.00003191694,0.0001675481,0.9302151,0.00005930091,0.0001919829,0.002874042,0.0003070961,0.005867671,0.05402332,0.0005396277,0.005700327,0.00002221374],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993001,0.0005408279,0.001925945,0.0001096517,0.00001836387,0.00002676936,0.002914484,0.00005779999,0.001405277],"genre_scores_gemma":[0.994538,0.0001275018,0.001603475,0.0001019309,0.00001495259,0.00001995895,0.003157247,0.00003128265,0.000405748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002038659,"threshold_uncertainty_score":0.006819963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08786800377398649,"score_gpt":0.4300727374856115,"score_spread":0.3422047337116251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}