{"id":"W4390937411","doi":"10.1016/j.omtm.2024.101189","title":"High-titer manufacturing of SARS-CoV-2 Spike-pseudotyped VSV in stirred-tank bioreactors","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Titer; Virology; Bioreactor; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Spike (software development); 2019-20 coronavirus outbreak; Biology; Medicine; Virus; Engineering; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001330522,0.0009611309,0.0008829672,0.0003961594,0.0003934698,0.000939853,0.0008018119,0.0008733594,0.0006440673],"category_scores_gemma":[0.0007506351,0.0003815979,0.0009505733,0.0005232967,0.0003243465,0.0004740222,0.00057444,0.001281836,0.001029008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008362293,"about_ca_system_score_gemma":0.0005679985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002046631,"about_ca_topic_score_gemma":0.002372349,"domain_scores_codex":[0.9988675,0.0002272762,0.0001511244,0.0002095095,0.0004300274,0.0001146254],"domain_scores_gemma":[0.9996043,0.0001196056,0.00007945345,0.00005837527,0.00009353426,0.00004467906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004287798,0.00004542213,0.0001043463,0.0000380987,0.000006586415,0.00004225583,0.00003105962,0.0004757745,0.9983493,0.00005614424,0.00006012705,0.0007481273],"study_design_scores_gemma":[0.00001904749,0.0004424929,0.0005509264,0.00001005809,0.00001787159,0.00005776293,0.0000343285,0.004336966,0.9933169,0.00005014135,0.001148169,0.00001527066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.872741,0.001280594,0.1178087,0.0003174446,0.0003393831,0.001032395,0.00216218,0.001009141,0.003309076],"genre_scores_gemma":[0.8282228,0.001836234,0.1581857,0.0001454031,0.00008658665,0.0009420411,0.00413893,0.0002366975,0.006205598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046631,"threshold_uncertainty_score":0.007036567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1464855276766287,"score_gpt":0.4951134594821829,"score_spread":0.3486279318055542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}