{"id":"W4390944133","doi":"10.3138/jammi-2022-0039","title":"Testing the limits of multiplex respiratory virus assays for SARS-CoV-2 at high cycle threshold values: Comparative performance of cobas 6800/8800 SARS-CoV-2 & Influenza A/B, Xpert Xpress SARS-CoV-2/Flu/RSV, and cobas Liat SARS-CoV-2 & Influenza A/B","year":2024,"lang":"en","type":"article","venue":"Journal of the Association of Medical Microbiology and Infectious Disease Canada","topic":"Respiratory viral infections research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Multiplex; Virology; Human metapneumovirus; GeneXpert MTB/RIF; Viral load; Medicine; Multiplex polymerase chain reaction; Respiratory system; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Virus; Biology; Respiratory tract infections; Sputum; Polymerase chain reaction; Tuberculosis; Internal medicine; Pathology; Gene; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01003182,0.00113245,0.0006021231,0.001445161,0.0004516881,0.001245583,0.0008484235,0.00124611,0.001051992],"category_scores_gemma":[0.01629613,0.0009528256,0.0004689141,0.0007757628,0.001261381,0.001103079,0.0009594498,0.0007607866,0.0005672792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006828076,"about_ca_system_score_gemma":0.0004750123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009370066,"about_ca_topic_score_gemma":0.001024869,"domain_scores_codex":[0.9873657,0.004312575,0.0008886061,0.00274305,0.004223166,0.000466738],"domain_scores_gemma":[0.9833734,0.01144432,0.002013673,0.0009563991,0.001907089,0.0003050705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003658412,0.0005741162,0.1559826,0.000591065,0.0003086037,0.000201821,0.00176166,0.005415157,0.774911,0.0007786494,0.000361278,0.05545554],"study_design_scores_gemma":[0.0001056984,0.004327989,0.1223056,0.0001814755,0.0002857007,0.002393069,0.0004923073,0.03689905,0.8288833,0.0007683727,0.003249952,0.0001075518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519295,0.003324496,0.04174221,0.00009340481,0.00006947189,0.0001151473,0.000233854,0.0002550329,0.002237034],"genre_scores_gemma":[0.9568764,0.0005139112,0.04131867,0.00009735423,0.00003007254,0.0002269255,0.0002788122,0.00002381769,0.0006340494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01003182,"threshold_uncertainty_score":0.05305398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09680906841162397,"score_gpt":0.3763917616999942,"score_spread":0.2795826932883702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}