{"id":"W4390950175","doi":"10.1002/path.6238","title":"Image‐based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno‐oncology Biomarker Working Group on Breast Cancer","year":2024,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; University of Guelph; Sunnybrook Health Science Centre; Health Sciences Centre; BC Cancer Agency","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Servier; Incyte; Medical Research Council; Chugai Pharmaceutical; National Institutes of Health; Peter MacCallum Cancer Centre; Ligue Contre le Cancer; KU Leuven; DOD Prostate Cancer Research Program; Japan Society for the Promotion of Science; Astellas Pharma; Eisai; Fondation ARC pour la Recherche sur le Cancer; DOD Peer Reviewed Cancer Research Program; Ministerie van Volksgezondheid, Welzijn en Sport; Daiichi-Sankyo; Agence Nationale de la Recherche; Amgen; Science Foundation Ireland; AstraZeneca; Genentech; European Commission; Engineering and Physical Sciences Research Council; Yuhan; Irish Cancer Society; National Breast Cancer Foundation; Svenska Sällskapet för Medicinsk Forskning; KWF Kankerbestrijding; U.S. Department of Defense; Cancer Research UK; Seagen; Puma Biotechnology; Daiichi Sankyo Europe; Veracyte; Pfizer; Susan G. Komen; National Institute of Diabetes and Digestive and Kidney Diseases; Carrick Therapeutics; Gilead Sciences; GlaxoSmithKline; Sanofi; California Breast Cancer Research Program; National Health and Medical Research Council; Cancer Research Institute; Eli Lilly and Company; Bristol-Myers Squibb; Breast Cancer Research Foundation; Higher Education Authority; Silverback Therapeutics; U.S. Department of Veterans Affairs; Irish Research eLibrary","keywords":"Multiplex; Breast cancer; Biomarker; Oncology; Medicine; Profiling (computer programming); Internal medicine; Immune system; Cancer; Pathology; Bioinformatics; Immunology; Biology; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001966883,0.0003209919,0.001455734,0.0003905785,0.00007530747,0.00001040523,0.0006657963,0.0003060791,0.0002710143],"category_scores_gemma":[0.00007518552,0.000161889,0.001087143,0.0005280868,0.0005125864,0.00004191154,0.00007106418,0.0007643364,0.000001600997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004259758,"about_ca_system_score_gemma":0.001831662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001742076,"about_ca_topic_score_gemma":0.00006760316,"domain_scores_codex":[0.9965469,0.0004350578,0.002127653,0.000234751,0.0004423773,0.0002132199],"domain_scores_gemma":[0.9954731,0.0004354607,0.003083842,0.0005239752,0.0004448989,0.00003873492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002944852,0.0003610355,0.0006402789,0.003052323,0.003173493,0.0002693066,0.0003939818,0.00001128344,0.05450664,0.00004887863,0.000644009,0.9339539],"study_design_scores_gemma":[0.005095902,0.0007274979,0.02088176,0.0582297,0.01257479,0.04613638,0.0002330122,0.0001383552,0.001618141,0.0001564532,0.8536616,0.0005464139],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001742055,0.9885804,0.000152642,0.005957969,0.002179418,0.0008220331,0.0003161578,0.000009477353,0.000239815],"genre_scores_gemma":[0.01029925,0.9877431,0.0009359544,0.0001856749,0.000490945,0.0001019872,0.00005532286,0.00006210749,0.0001257099],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9334075,"threshold_uncertainty_score":0.6601644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07682459191772924,"score_gpt":0.4187375389506274,"score_spread":0.3419129470328982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}