{"id":"W4390950175","doi":"10.1002/path.6238","title":"Image‐based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno‐oncology Biomarker Working Group on Breast Cancer","year":2024,"lang":"en","type":"review","venue":"The Journal of Pathology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; University of Guelph; Sunnybrook Health Science Centre; Health Sciences Centre; BC Cancer Agency","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Servier; Incyte; Medical Research Council; Chugai Pharmaceutical; National Institutes of Health; Peter MacCallum Cancer Centre; Ligue Contre le Cancer; KU Leuven; DOD Prostate Cancer Research Program; Japan Society for the Promotion of Science; Astellas Pharma; Eisai; Fondation ARC pour la Recherche sur le Cancer; DOD Peer Reviewed Cancer Research Program; Ministerie van Volksgezondheid, Welzijn en Sport; Daiichi-Sankyo; Agence Nationale de la Recherche; Amgen; Science Foundation Ireland; AstraZeneca; Genentech; European Commission; Engineering and Physical Sciences Research Council; Yuhan; Irish Cancer Society; National Breast Cancer Foundation; Svenska Sällskapet för Medicinsk Forskning; KWF Kankerbestrijding; U.S. Department of Defense; Cancer Research UK; Seagen; Puma Biotechnology; Daiichi Sankyo Europe; Veracyte; Pfizer; Susan G. Komen; National Institute of Diabetes and Digestive and Kidney Diseases; Carrick Therapeutics; Gilead Sciences; GlaxoSmithKline; Sanofi; California Breast Cancer Research Program; National Health and Medical Research Council; Cancer Research Institute; Eli Lilly and Company; Bristol-Myers Squibb; Breast Cancer Research Foundation; Higher Education Authority; Silverback Therapeutics; U.S. Department of Veterans Affairs; Irish Research eLibrary","keywords":"Multiplex; Breast cancer; Biomarker; Oncology; Medicine; Profiling (computer programming); Internal medicine; Immune system; Cancer; Pathology; Bioinformatics; Immunology; Biology; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002667669,0.0008395679,0.001619416,0.003105979,0.0002593666,0.001789572,0.001081218,0.001870731,0.00174098],"category_scores_gemma":[0.001662546,0.0005019069,0.0006258243,0.001900906,0.001165495,0.002133309,0.001022911,0.002517019,0.001906306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009587936,"about_ca_system_score_gemma":0.001121977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007751993,"about_ca_topic_score_gemma":0.0009753281,"domain_scores_codex":[0.9994743,0.0001242999,0.00004574844,0.00009921426,0.0002078158,0.00004862003],"domain_scores_gemma":[0.9986948,0.0007181199,0.0001340904,0.00003706266,0.0003260076,0.00009003474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001110367,0.00009110271,0.000258477,0.009243462,0.0000901049,0.0002465125,0.0000920099,0.0004466305,0.005823486,0.007328394,0.02780127,0.9484675],"study_design_scores_gemma":[0.00002739623,0.0002314231,0.001167017,0.002686754,0.0001026274,0.002458846,0.0000797905,0.0003097735,0.00359707,0.003016599,0.986278,0.00004469972],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001066901,0.9983034,0.0003337568,0.0004226657,0.0002060124,0.000006961889,0.00001417984,0.000009683931,0.0005966634],"genre_scores_gemma":[0.001412623,0.9964615,0.0005747003,0.0005454679,0.0002386,0.00001766622,0.00004280286,0.000004534499,0.0007021911],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003105979,"threshold_uncertainty_score":0.01410812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07682459191772924,"score_gpt":0.4187375389506274,"score_spread":0.3419129470328982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}