{"id":"W4390953019","doi":"10.1016/j.intimp.2023.111452","title":"Arsenic trioxide alleviates atherosclerosis by inhibiting CD36-induced endocytosis and TLR4/NF-κB-induced inflammation in macrophage and ApoE-/- mice","year":2024,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Key Laboratory of Myocardial Ischemia, Ministry of Education; Natural Science Foundation of Heilongjiang Province; China Postdoctoral Science Foundation; Ministry of Education of the People's Republic of China; Second Affiliated Hospital of Harbin Medical University; National Natural Science Foundation of China; Heilongjiang Postdoctoral Science Foundation; Postdoctoral Foundation of Hei Long Jiang Province; Harbin Medical University","keywords":"CD36; Inflammation; Inflammasome; TLR4; Foam cell; Arsenic trioxide; Pyroptosis; Scavenger receptor; Chemistry; Tumor necrosis factor alpha; Pharmacology; Macrophage; Cancer research; Medicine; Lipoprotein; Receptor; Apoptosis; Immunology; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000282829,0.0002233225,0.0001857213,0.0001398275,0.00007039205,0.0001187268,0.0002023736,0.00022053,0.00005849442],"category_scores_gemma":[0.0001037748,0.0002311154,0.00005815983,0.0001137014,0.00007911375,0.00003387936,0.0002069424,0.0002682782,0.00001341677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007709458,"about_ca_system_score_gemma":0.00007484951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008345953,"about_ca_topic_score_gemma":0.0000138145,"domain_scores_codex":[0.9985983,0.0001123739,0.0003978668,0.0004942765,0.000137264,0.0002599337],"domain_scores_gemma":[0.9995769,0.00009968764,0.0001017035,0.0000892454,0.00007490236,0.00005762017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000948301,0.00002880394,0.0005213359,0.00005641529,0.0001429858,0.00001841711,0.0001873198,0.000006517898,0.9900082,0.00006347532,0.0002298221,0.008641851],"study_design_scores_gemma":[0.001188289,0.0001331502,0.0004789906,0.00006483231,0.00003237333,0.00007247512,0.0001052643,0.0006845099,0.991142,0.00008019792,0.00579549,0.0002223783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921337,0.005880314,0.0000666925,0.0005993838,0.0005683206,0.0002111823,0.00002480109,0.00003228501,0.000483289],"genre_scores_gemma":[0.9952407,0.003490369,0.0001185097,0.0002436088,0.0002464537,0.00008962566,0.0001255551,0.00003519571,0.0004099528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008419473,"threshold_uncertainty_score":0.9424613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009021285930747388,"score_gpt":0.2710643756133363,"score_spread":0.2620430896825889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}