{"id":"W4390953300","doi":"10.20944/preprints202401.1118.v1","title":"Lessons from the Thioredoxin-1 Knockout Mouse Models","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Thioredoxin; Glutaredoxin; Thioredoxin reductase; Cell biology; Glutathione; Transgene; Genetically modified mouse; Antioxidant; Reactive oxygen species; Cysteine; Function (biology); Biochemistry; Biology; Chemistry; Oxidative stress; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00203294,0.001131961,0.001416565,0.001474326,0.0003365064,0.00156281,0.001588882,0.002582155,0.002168085],"category_scores_gemma":[0.002242915,0.0004109425,0.00073702,0.0006047621,0.001928155,0.001872425,0.001063335,0.006509362,0.001291991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007045895,"about_ca_system_score_gemma":0.0005505348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005206376,"about_ca_topic_score_gemma":0.0007315766,"domain_scores_codex":[0.9993858,0.0001323576,0.00008065641,0.0001637481,0.0001822054,0.00005519363],"domain_scores_gemma":[0.9989937,0.0004294697,0.0001237057,0.000143527,0.0001777264,0.00013189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001242937,0.0005409396,0.003949867,0.00612427,0.0004668722,0.009014766,0.0007708389,0.001752004,0.1886458,0.1756054,0.1053388,0.5065476],"study_design_scores_gemma":[0.0001739294,0.0007620923,0.007856051,0.002913288,0.0005001313,0.02327221,0.0004601446,0.001203693,0.0401856,0.2291359,0.6933523,0.0001845888],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07497795,0.663198,0.08976872,0.1195943,0.008555247,0.00009715874,0.003412729,0.002743879,0.03765197],"genre_scores_gemma":[0.1451061,0.7552587,0.04216865,0.03286498,0.006216917,0.0002912735,0.002285943,0.0007952552,0.01501221],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002582155,"threshold_uncertainty_score":0.01075131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.116670544585161,"score_gpt":0.3647170804128574,"score_spread":0.2480465358276964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}