{"id":"W4390953957","doi":"10.1101/2024.01.15.575754","title":"The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cytidine deaminase; Biology; Genetics; Genome; APOBEC; Mutagenesis; Genome instability; Human genome; Mutation; Gene; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000857262,0.0001320398,0.0001367021,0.0001618719,0.0001900391,0.0003407576,0.00007874802,0.0001756265,0.001415549],"category_scores_gemma":[0.0001000747,0.00007002064,0.0001453623,0.0002190163,0.0001226707,0.00008821607,0.0001589888,0.0003209567,0.0005411358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117934,"about_ca_system_score_gemma":0.0001535076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002254253,"about_ca_topic_score_gemma":0.002400908,"domain_scores_codex":[0.9999348,0.000005837728,0.000002977834,0.00001925965,0.00002417457,0.00001294471],"domain_scores_gemma":[0.9999442,0.000009653393,0.00001176717,0.000008946628,0.00001391898,0.00001146863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004321155,0.000009082129,0.001155186,0.00001583152,0.000003214119,0.00004626894,0.00001030835,0.0001240554,0.9944816,0.0004571428,0.0002003489,0.003453879],"study_design_scores_gemma":[0.00001085275,0.00007199533,0.01588719,0.000005501949,0.00001389989,0.0009209111,0.00003337433,0.001931312,0.9678059,0.0004486027,0.01286302,0.00000748482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753126,0.001589005,0.01193085,0.0002281535,0.00003979502,0.00002256242,0.001219048,0.0001841047,0.009474013],"genre_scores_gemma":[0.9870379,0.0003436958,0.005980455,0.00005572212,0.0000110488,0.00001134743,0.001350678,0.00003292488,0.005176121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002254253,"threshold_uncertainty_score":0.00473547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526731627199917,"score_gpt":0.2435829633272457,"score_spread":0.2183156470552465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}