{"id":"W4390954078","doi":"10.1002/cmdc.202300704","title":"Front Cover: Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication (ChemMedChem 2/2024)","year":2024,"lang":"en","type":"paratext","venue":"ChemMedChem","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Xenon Pharmaceuticals (Canada); Université de Sherbrooke","funders":"","keywords":"Transmembrane protein; Proteases; Serine protease; Front cover; Cleavage (geology); Chemistry; Serine; Protease; Peptidomimetic; Virology; Cover (algebra); Stereochemistry; Biology; Biochemistry; Enzyme; Receptor; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.0008723193,0.001276222,0.002075174,0.001021878,0.0002522237,0.00008556682,0.0006410754,0.00119339,0.006623512],"category_scores_gemma":[0.001442746,0.001202627,0.000584802,0.001839043,0.0003637086,0.0001882161,0.000533458,0.001857633,0.005880431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001548945,"about_ca_system_score_gemma":0.002015788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003872021,"about_ca_topic_score_gemma":0.00001775648,"domain_scores_codex":[0.9929987,0.000102681,0.001889228,0.002012171,0.001848388,0.00114883],"domain_scores_gemma":[0.994187,0.000173155,0.0006086207,0.002461785,0.001736155,0.0008333107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003543164,0.0008660358,0.00003149176,0.01049057,0.001007905,0.00005440653,0.001009402,0.01423761,0.3201049,0.000007106494,0.6465561,0.002091334],"study_design_scores_gemma":[0.001963158,0.0007120892,0.00001447701,0.002306703,0.0004615494,0.00001459803,0.00005990937,0.002085268,0.668732,0.00000360517,0.3229511,0.0006955618],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.3221519,0.07743604,0.00417822,0.02385393,0.01416725,0.05300071,0.008290992,0.002918077,0.4940029],"genre_scores_gemma":[0.1872617,0.008017392,0.0300671,0.02111156,0.01042389,0.009942948,0.01129766,0.003105728,0.718772],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.3486271,"threshold_uncertainty_score":0.999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05846849861128866,"score_gpt":0.3610581834253033,"score_spread":0.3025896848140146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}