{"id":"W4390954078","doi":"10.1002/cmdc.202300704","title":"Front Cover: Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication (ChemMedChem 2/2024)","year":2024,"lang":"en","type":"paratext","venue":"ChemMedChem","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Xenon Pharmaceuticals (Canada); Université de Sherbrooke","funders":"","keywords":"Transmembrane protein; Proteases; Serine protease; Front cover; Cleavage (geology); Chemistry; Serine; Protease; Peptidomimetic; Virology; Cover (algebra); Stereochemistry; Biology; Biochemistry; Enzyme; Receptor; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007326707,0.0005743993,0.00028801,0.0003597378,0.0001576186,0.0002017932,0.0003389859,0.0002643255,0.0862466],"category_scores_gemma":[0.00006286545,0.0001250522,0.0001801082,0.0002884499,0.00005578195,0.0002084504,0.000190559,0.0003147208,0.02519753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002444387,"about_ca_system_score_gemma":0.0001487623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000436393,"about_ca_topic_score_gemma":0.001341276,"domain_scores_codex":[0.9999582,0.000002928606,0.000001283314,0.000005355945,0.00002094012,0.00001127044],"domain_scores_gemma":[0.9999819,0.000002364338,0.000003752734,0.000001022069,0.000003297509,0.000007666844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002353131,0.0005853195,0.0001397141,0.001969556,0.00003176331,0.0003467592,0.0000394449,0.001886663,0.4921758,0.002750254,0.2103641,0.2873576],"study_design_scores_gemma":[0.0005585705,0.003265434,0.003768912,0.0001709429,0.00006244803,0.0006512424,0.00002458743,0.00235578,0.2782685,0.0006307607,0.7102082,0.00003458219],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.1586441,0.1004906,0.01301332,0.003427003,0.005695414,0.0007100119,0.01346887,0.002745815,0.7018048],"genre_scores_gemma":[0.2639914,0.07114246,0.008006464,0.001502792,0.001351445,0.0003391059,0.009205633,0.0003222575,0.6441384],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.0862466,"threshold_uncertainty_score":0.2885237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05846849861128866,"score_gpt":0.3610581834253033,"score_spread":0.3025896848140146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}