{"id":"W4390955842","doi":"10.1111/exd.15011","title":"The impacts of biologic treatment on metabolic profiling in psoriasis","year":2024,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Fundamental Research Funds for Central Universities of the Central South University; Fundamental Research Funds for the Central Universities; Central South University; National Natural Science Foundation of China","keywords":"Psoriasis; Metabolome; Internal medicine; Medicine; Resistin; Adalimumab; Lysophosphatidylcholine; Metabolite; Endocrinology; Lysophosphatidylethanolamine; Gastroenterology; Chemistry; Adipokine; Disease; Immunology; Leptin; Phospholipid; Obesity; Phosphatidylcholine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000939212,0.0002386083,0.0003866986,0.0001754339,0.000126663,0.00001432439,0.0001594398,0.0002063657,0.0001042721],"category_scores_gemma":[0.00001936922,0.0001376064,0.0001603238,0.0001976239,0.0002016431,0.00004799091,0.00004158061,0.0001018694,0.0004065594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008509513,"about_ca_system_score_gemma":0.00007106589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001335499,"about_ca_topic_score_gemma":0.00005249332,"domain_scores_codex":[0.9986061,0.0003095153,0.0003538311,0.0003095315,0.00002817832,0.0003928107],"domain_scores_gemma":[0.9992837,0.0003746929,0.00006172436,0.0002495634,0.00001034153,0.00001993352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006922744,0.0007230504,0.014017,0.00001889065,0.0008199784,0.0001733552,0.001665491,0.000003108642,0.9121692,0.0422099,0.0004354006,0.02707236],"study_design_scores_gemma":[0.001267485,0.0004087985,0.003100962,0.00002440417,0.00004368744,0.0002382548,0.0005828565,0.000005277058,0.9780243,0.000112235,0.01606715,0.0001245591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8940485,0.1024583,0.000001373193,0.0002270132,0.001500282,0.0003117739,0.00002958601,0.00006845605,0.001354704],"genre_scores_gemma":[0.9979267,0.001424073,0.00003499578,0.00004205115,0.00002737305,0.0001991057,0.0000684878,0.00001639983,0.0002607811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1038782,"threshold_uncertainty_score":0.5611426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0214783976311967,"score_gpt":0.2908079678322688,"score_spread":0.2693295702010721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}