{"id":"W4390966613","doi":"10.1016/j.neurobiolaging.2024.01.005","title":"Brain structural indicators of β-amyloid neuropathology","year":2024,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; University of Oxford; Hankuk University of Foreign Studies; Genentech; University of Cambridge; IXICO; H. Lundbeck A/S; Servier; Siemens Healthineers; Eisai; Northern California Institute for Research and Education; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Neuropathology; Amyloid (mycology); Neuroscience; Medicine; Pathology; Psychology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000275814,0.0002362115,0.0001438959,0.0009274972,0.00009296331,0.0002070083,0.00009551906,0.0001340281,0.00105219],"category_scores_gemma":[0.0006216411,0.00009698528,0.00009100125,0.0003186727,0.0002039105,0.0002223197,0.0001941348,0.000178796,0.000121288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009090532,"about_ca_system_score_gemma":0.00009100264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004288146,"about_ca_topic_score_gemma":0.0008921539,"domain_scores_codex":[0.9999375,0.0000154343,0.000005732617,0.00001440798,0.00002035002,0.000006501577],"domain_scores_gemma":[0.9997792,0.00003806542,0.00009570458,0.00002022997,0.0000412097,0.00002555686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005044229,0.00008935894,0.1343833,0.0001741743,0.0001662289,0.0002228744,0.0002639279,0.001200876,0.791869,0.0008453967,0.0004636502,0.06981681],"study_design_scores_gemma":[0.00001261568,0.0004187245,0.9222709,0.00001842411,0.00005711913,0.001360038,0.0001197838,0.003088204,0.07036083,0.001215842,0.001063317,0.00001412891],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915437,0.0009399915,0.005417626,0.00004332584,0.000007112955,0.00001413354,0.0002126614,0.0000629602,0.001758588],"genre_scores_gemma":[0.9944217,0.0003117733,0.004751598,0.00001351772,0.000008896734,0.00001168427,0.0001352528,0.000005307596,0.00034029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105219,"threshold_uncertainty_score":0.003519952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523209002908905,"score_gpt":0.3173749814583275,"score_spread":0.3021428914292384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}