{"id":"W4390968570","doi":"10.1016/b978-0-443-19061-2.00010-9","title":"Clinical translation of gold nanoparticles: obstacles and perspectives","year":2024,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Nanomedicine; Medicine; Risk analysis (engineering); Preclinical testing; Drug development; Medical physics; Computer science; Nanotechnology; Drug; Pharmacology; Nanoparticle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009735245,0.0007576643,0.001087642,0.0009540753,0.0005706814,0.005908248,0.001694739,0.006044788,0.02050938],"category_scores_gemma":[0.0056925,0.0003897615,0.0006038282,0.0005841305,0.00295357,0.004917107,0.001897291,0.00573148,0.007575632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001966195,"about_ca_system_score_gemma":0.003647094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001746229,"about_ca_topic_score_gemma":0.003372938,"domain_scores_codex":[0.9983517,0.0006997342,0.0001023841,0.0001673355,0.0005417373,0.0001371264],"domain_scores_gemma":[0.9935684,0.004859467,0.0002125821,0.0002249035,0.0007727426,0.0003620032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000322934,0.0002775622,0.0002917179,0.002053922,0.00002866886,0.0008415369,0.0005310266,0.0008364728,0.008919156,0.1392164,0.1867144,0.6599661],"study_design_scores_gemma":[0.00006465774,0.0003947322,0.0002872481,0.001432349,0.00001986575,0.0009447308,0.0003262363,0.0004526965,0.003914583,0.04598022,0.9461542,0.00002852239],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002832197,0.6755729,0.01509226,0.2052288,0.01389356,0.00009379202,0.0002712571,0.0003657398,0.08664948],"genre_scores_gemma":[0.03734156,0.7629319,0.02690504,0.07666519,0.01605341,0.0002866701,0.0004227668,0.0004604381,0.07893299],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02050938,"threshold_uncertainty_score":0.06861073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03925942789855546,"score_gpt":0.2827038384945019,"score_spread":0.2434444105959464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}