{"id":"W4390973753","doi":"10.1051/bioconf/20248601038","title":"OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment","year":2024,"lang":"en","type":"article","venue":"BIO Web of Conferences","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lambton College","funders":"Chitkara University","keywords":"Cancer; Mechanism (biology); Computer science; Medicine; Epistemology; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006100411,0.00009438895,0.00009431542,0.00006270471,0.00001511984,0.00002298542,0.00008544663,0.00006136097,0.0001291087],"category_scores_gemma":[0.000007074473,0.00007049742,0.00004643125,0.00009084739,0.00004392692,0.000003959069,0.00001909168,0.00002823049,0.000004035979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001639385,"about_ca_system_score_gemma":0.0005491795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000168995,"about_ca_topic_score_gemma":0.0002440284,"domain_scores_codex":[0.9994534,0.00001804765,0.0001511717,0.0001881567,0.00008132442,0.0001079238],"domain_scores_gemma":[0.9998068,0.000004340716,0.00003409143,0.0001000074,0.00002956197,0.00002522659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005331511,0.000219799,0.07058996,0.00008401815,0.0001738042,0.000003710803,0.000189478,0.00001579163,0.808531,0.003098857,0.0007807876,0.1162595],"study_design_scores_gemma":[0.0003979707,0.0002757701,0.009574845,0.0001234826,0.0000151013,0.000001473379,0.0001130817,0.0008137663,0.6374213,0.00007254997,0.3510481,0.0001426032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862152,0.0072403,0.0001851929,0.0006399099,0.0003453754,0.0003314345,0.000024921,0.00001580308,0.005001891],"genre_scores_gemma":[0.9976746,0.001110021,0.00003975054,0.00005066782,0.00009355957,0.00009375987,0.00002531613,0.000006519384,0.0009057706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3502673,"threshold_uncertainty_score":0.2874801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06051286820310344,"score_gpt":0.338459078503749,"score_spread":0.2779462103006455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}