{"id":"W4390982281","doi":"10.3389/fcell.2024.1298007","title":"hiPSC-derived cardiomyocytes as a model to study the role of small-conductance Ca2+-activated K+ (SK) ion channel variants associated with atrial fibrillation","year":2024,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital; Simon Fraser University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Ministerio de Ciencia e Innovación; BC Children's Hospital; Michael Smith Health Research BC; Stem Cell Network; National Institutes of Health; Children's Hospital Foundation","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Potassium channel; Atrial fibrillation; SNP; Context (archaeology); Genetic association; Electrophysiology; Bioinformatics; Ion channel; Neuroscience; Biology; Computational biology; Medicine; Genetics; Internal medicine; Gene; Genotype; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009313932,0.0002605531,0.0005742624,0.0006765472,0.0005113552,0.0005703122,0.0004677648,0.0008897917,0.00431158],"category_scores_gemma":[0.0004800775,0.0001966829,0.0006009025,0.0006033499,0.0003550042,0.0003545791,0.0005413487,0.001888587,0.001592386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927899,"about_ca_system_score_gemma":0.0004019881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708529,"about_ca_topic_score_gemma":0.002807087,"domain_scores_codex":[0.9992478,0.0001119102,0.00008513858,0.0001297364,0.0003144223,0.0001108383],"domain_scores_gemma":[0.9996141,0.0000990213,0.00005719835,0.00007124297,0.00006814357,0.00009018718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001098327,0.0006415447,0.003512073,0.0007287452,0.0001424038,0.002751874,0.0002344662,0.0009405626,0.9697353,0.002444527,0.004973641,0.01279658],"study_design_scores_gemma":[0.001028618,0.006180731,0.05936918,0.0004145389,0.0007561099,0.009345513,0.001147681,0.0137299,0.7971409,0.002080777,0.1086715,0.0001344261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8842121,0.02360499,0.04223935,0.002668927,0.00242904,0.001193177,0.01744064,0.0008280685,0.02538365],"genre_scores_gemma":[0.9391502,0.009079987,0.02123648,0.001806588,0.0002994591,0.001383548,0.009460515,0.0001317412,0.0174515],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00431158,"threshold_uncertainty_score":0.01442373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02638045140812614,"score_gpt":0.272142185610308,"score_spread":0.2457617342021818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}