{"id":"W4390990733","doi":"10.1016/j.ymthe.2024.01.021","title":"Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Fondation Voir et Entendre; Foundation Fighting Blindness; European Commission; Agence Nationale de la Recherche; Fondation de France; Fondation Pour l'Audition","keywords":"Hearing loss; Audiology; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003073229,0.000213543,0.0002250012,0.0002674097,0.00006394394,0.0001461358,0.0003312076,0.00009794709,0.00004282303],"category_scores_gemma":[0.0000875705,0.0002198669,0.0001000459,0.0005347768,0.00009933569,0.0001873013,0.0001492827,0.0002974787,0.00001555057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008138867,"about_ca_system_score_gemma":0.0001430957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001283543,"about_ca_topic_score_gemma":0.00001649266,"domain_scores_codex":[0.9978569,0.0001797833,0.000434911,0.0005943746,0.0004847267,0.0004493504],"domain_scores_gemma":[0.9993037,0.0000642541,0.00007672672,0.0004303095,0.0000456425,0.00007937882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006520309,0.00009444886,0.001548848,0.00008254125,0.0000151029,0.0002004895,0.001367386,0.02466486,0.9666634,0.001224697,0.00001468765,0.004058362],"study_design_scores_gemma":[0.0005951538,0.0001195438,0.001048254,0.0001050351,0.000005193774,0.0000209541,0.00002960071,0.09758633,0.8983357,0.001729391,0.0002348512,0.0001899813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884832,0.001373593,0.008388113,0.0004640472,0.0001011407,0.0006667197,0.00001540472,0.0001020884,0.0004057029],"genre_scores_gemma":[0.9949967,0.0003543618,0.003959052,0.0003065405,0.00003172551,0.00008331413,0.00000724373,0.00006947432,0.0001916078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07292148,"threshold_uncertainty_score":0.8965913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07520665742255302,"score_gpt":0.3384143787508994,"score_spread":0.2632077213283464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}