{"id":"W4391013714","doi":"10.1038/s41594-025-01492-x","title":"Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)","year":2025,"lang":"en","type":"review","venue":"Nature Structural & Molecular Biology","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; McGill University","funders":"National Institute of General Medical Sciences; Wellcome Trust","keywords":"Interpretation (philosophy); Computational biology; Gene; Dual (grammatical number); Expression (computer science); Genetics; Biology; Cell biology; Computer science; Programming language; Linguistics; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005321355,0.0004352365,0.001012809,0.0001358828,0.0001023299,0.00001694705,0.0003341602,0.00118792,0.000001867816],"category_scores_gemma":[0.002591199,0.0002933035,0.0004589014,0.0001527348,0.0002688989,0.000006512672,0.0003833122,0.000300784,3.852636e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002103571,"about_ca_system_score_gemma":0.0002110651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008924058,"about_ca_topic_score_gemma":9.372191e-7,"domain_scores_codex":[0.9965377,0.0003736917,0.00192562,0.0007838974,0.0001124193,0.0002666193],"domain_scores_gemma":[0.995644,0.0001146784,0.002950138,0.0007426213,0.0005029663,0.00004562433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009185363,0.00001347769,0.00002881968,0.001512295,0.0003885453,0.000005728276,0.00001950778,0.00002237362,0.8802373,0.0004024935,0.0007893349,0.1164882],"study_design_scores_gemma":[0.0004853497,0.0007443184,0.00002046608,0.003667041,0.001073631,0.0002877137,0.00003017011,0.0004029892,0.9051836,0.0006568767,0.08672354,0.0007243201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004555394,0.8590182,0.1339621,0.00006324879,0.000209228,0.002051541,0.0001216451,0.00001363881,0.000005025651],"genre_scores_gemma":[0.02262987,0.6691277,0.3030415,0.0005349084,0.0001585941,0.0007429283,0.003590991,0.00008404559,0.00008946311],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1898905,"threshold_uncertainty_score":0.9999519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1077162116898085,"score_gpt":0.4510750795127754,"score_spread":0.3433588678229669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}