{"id":"W4391013714","doi":"10.1038/s41594-025-01492-x","title":"Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)","year":2025,"lang":"en","type":"review","venue":"Nature Structural & Molecular Biology","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; McGill University","funders":"National Institute of General Medical Sciences; Wellcome Trust","keywords":"Interpretation (philosophy); Computational biology; Gene; Dual (grammatical number); Expression (computer science); Genetics; Biology; Cell biology; Computer science; Programming language; Linguistics; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.05107546,0.002777312,0.004322414,0.01039819,0.002130746,0.00555262,0.01241384,0.007485561,0.02053567],"category_scores_gemma":[0.04335571,0.003161583,0.003333197,0.006596684,0.003813809,0.003471273,0.004186586,0.007309588,0.03326406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002698443,"about_ca_system_score_gemma":0.01349411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004376064,"about_ca_topic_score_gemma":0.005710275,"domain_scores_codex":[0.9693139,0.01211255,0.00640439,0.001645871,0.009255393,0.001267829],"domain_scores_gemma":[0.939271,0.02308637,0.005133769,0.007490442,0.02344807,0.001570242],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006645554,0.0004647834,0.0003560863,0.03562751,0.0002262242,0.001026602,0.0007095933,0.0007705648,0.04409025,0.04349633,0.4359561,0.4366114],"study_design_scores_gemma":[0.0001502434,0.0001910092,0.001036488,0.005602393,0.0001804109,0.0007930088,0.000157,0.0002893801,0.01582066,0.007993176,0.9677041,0.00008200673],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.003908944,0.320923,0.4649054,0.02934277,0.01442121,0.02124406,0.03689296,0.02046826,0.08789354],"genre_scores_gemma":[0.007785319,0.2106837,0.6328485,0.01219109,0.002233076,0.03697197,0.04711568,0.00225105,0.04791967],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.9489245,"threshold_uncertainty_score":0.2701161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1077162116898085,"score_gpt":0.4510750795127754,"score_spread":0.3433588678229669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}