{"id":"W4391015083","doi":"10.1021/acs.jmedchem.3c01278","title":"Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Impact; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Institute on Drug Abuse; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Monoacylglycerol lipase; Chemistry; Serine hydrolase; Enzyme; Serine; In vitro; Lipase; In vivo; Biochemistry; Combinatorial chemistry; Endocannabinoid system; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184921,0.0005088598,0.0004282352,0.000223352,0.0001489994,0.0003778732,0.0005175477,0.000280204,0.0007534731],"category_scores_gemma":[0.0001335798,0.0001518109,0.0003271427,0.0002057683,0.0001678132,0.0002235696,0.0002140571,0.0005992259,0.0004711607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006111877,"about_ca_system_score_gemma":0.0004900647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000923801,"about_ca_topic_score_gemma":0.002525573,"domain_scores_codex":[0.9999205,0.00001041917,0.000007073932,0.00001361649,0.00002882875,0.00001961027],"domain_scores_gemma":[0.999962,0.000003664555,0.00001009249,0.000004019191,0.000008604452,0.00001164795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001908917,0.0001394278,0.0002067771,0.0001713683,0.00003074059,0.0001202938,0.00002870173,0.001441949,0.9866171,0.0005070652,0.0001894703,0.01035636],"study_design_scores_gemma":[0.0001383043,0.001125637,0.001125602,0.00001461403,0.0000709283,0.0003537143,0.00002385683,0.004181897,0.9829115,0.00008944824,0.009946934,0.00001758033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519696,0.01635791,0.02282709,0.0003264215,0.00008492384,0.000439615,0.000969975,0.0002441217,0.006780392],"genre_scores_gemma":[0.9716475,0.007162678,0.0144302,0.0001407212,0.00001914013,0.0001439166,0.002003433,0.00002158931,0.004430874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000923801,"threshold_uncertainty_score":0.004434466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354724974747118,"score_gpt":0.2952625077026504,"score_spread":0.2817152579551793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}