{"id":"W4391019489","doi":"10.1371/journal.ppat.1011957","title":"Unmutated but T cell dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; International Development Research Centre","keywords":"Streptococcus suis; Biology; Somatic hypermutation; Antibody; Germinal center; Microbiology; Isotype; Immunoglobulin class switching; B cell; Immunology; Virology; Immune system; T cell; Virulence; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117718,0.0003748848,0.0002118787,0.0002125979,0.0000657273,0.0002253489,0.0001431064,0.0002700432,0.0009957545],"category_scores_gemma":[0.0000877983,0.00008610963,0.0001609508,0.00007292162,0.0001705627,0.0001456076,0.0001254874,0.0003644723,0.0003257167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001509305,"about_ca_system_score_gemma":0.0001601475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003160236,"about_ca_topic_score_gemma":0.0003736994,"domain_scores_codex":[0.9998809,0.0000211756,0.00001373531,0.00001750946,0.00003196182,0.00003478547],"domain_scores_gemma":[0.999905,0.00001093098,0.00002706382,0.00001010516,0.00001926745,0.00002765235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075651,0.00001894911,0.0004206985,0.00003214848,0.000002887013,0.00004709244,0.000005620084,0.00003607306,0.9977223,0.00005189296,0.0000358593,0.00151892],"study_design_scores_gemma":[0.00001708027,0.0006504966,0.01128746,0.000009784048,0.00002517473,0.0003979908,0.00003442071,0.0007224859,0.9836785,0.00008918835,0.003083761,0.000003682728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915355,0.00296481,0.002973314,0.0001190852,0.00005574488,0.00002529333,0.0003073434,0.0001426408,0.001876223],"genre_scores_gemma":[0.9950083,0.0008486211,0.001064111,0.00006682908,0.0000155602,0.00002446163,0.0002387142,0.00001243885,0.00272093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009957545,"threshold_uncertainty_score":0.003331125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273674029618241,"score_gpt":0.2715052376179724,"score_spread":0.25876849732179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}