{"id":"W4391019489","doi":"10.1371/journal.ppat.1011957","title":"Unmutated but T cell dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; International Development Research Centre","keywords":"Streptococcus suis; Biology; Somatic hypermutation; Antibody; Germinal center; Microbiology; Isotype; Immunoglobulin class switching; B cell; Immunology; Virology; Immune system; T cell; Virulence; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075504,0.0002598983,0.0003447132,0.0002121275,0.0001103871,0.0001069603,0.00006994075,0.0001392434,0.0007357371],"category_scores_gemma":[0.00004129202,0.0002260679,0.0001286621,0.000288659,0.00005206901,0.0001776235,0.00005144223,0.0002625505,0.0002508795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125563,"about_ca_system_score_gemma":0.0001049869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002560296,"about_ca_topic_score_gemma":0.0001173302,"domain_scores_codex":[0.9983222,0.000080829,0.0003738996,0.0005533557,0.0002399587,0.0004297534],"domain_scores_gemma":[0.9993851,0.00005523577,0.00005421025,0.0002653626,0.00006842198,0.0001716383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001588569,0.00102647,0.2476932,0.0001325607,0.0001487685,0.001186084,0.0006009958,0.00006166377,0.7473415,0.0000215716,0.00004782079,0.001580536],"study_design_scores_gemma":[0.003766435,0.0009989562,0.2524407,0.0005843015,0.0005697879,0.00007087942,0.0009023688,0.006931895,0.7321442,0.0001137053,0.0008598416,0.0006169179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964476,0.0004473198,0.00002945294,0.00003699472,0.0004655669,0.0007566016,0.0002487941,0.000257078,0.001310579],"genre_scores_gemma":[0.9982399,0.00008294176,0.0003132206,0.00001760824,0.0004373859,0.0001165517,0.0003313388,0.00005503586,0.0004059811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01519724,"threshold_uncertainty_score":0.9218782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273674029618241,"score_gpt":0.2715052376179724,"score_spread":0.25876849732179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}